Encapsulated pharmaceutical agents
OwnerIan Cottrell, Albert Ahn +1inventors
InventorsIan Cottrell, Albert Ahn, Richard Fisher
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Abstract
The present invention provides stable lipid-based pharmaceutical formulations containing ivermectin, praziquantel and pyrantel pamoate, and methods for preparing the formulations. Further provided is a method of treating helminthiasis of mammals, which comprises administering a pharmaceutical composition that is highly effective against helminths, particularly tapeworm, hookworm, roundworm and heartworm of domestic animals and farm animals.
Claims30
A method for forming an anthelmintic formulation, comprising the steps of:
- (a) combining a mixture of dried active ingredients of which at least one will degrade in the presence of at least one of others, comprising a macrocyclic lactone, a tetrahydropyrimidine and a hexahydropyrazinoisoquinoline with a composition comprising melted lipids, thereby forming a pourable active composition, wherein at least one of the macrocyclic lactone and the hexahydropyrazinoisoquinoline is present in the mixture as an encapsulated or coated particle;
- (b) transferring the pourable active composition into a container;
- (c) allowing the pourable active composition to cool and form a solid-like composition.
A pharmaceutical formulation comprising a lipid containing composition comprising at least two active ingredients that adversely react with each other, wherein at least one of the active ingredients is present in the formulation as encapsulated particles.
A method for treating or preventing helminthiasis in mammals, said method comprising administering an anthelmintically effective amount of the multidrug composition of embodiment 5 to the mammal.
Dependencies are inferred from the claim text.