Oral pharmaceutical formulations and methods for producing and using same
AssigneeConforma Therapeutics Corporation
InventorsRobert Mansfield, Edgar Ulm, Gregg Timony
Life of this patent
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Abstract
Oral pharmaceutical formulations and methods of producing and using the same are described and claimed. The formulations are dispersions of phospholipids and one or more pharmacologically active compounds, In preferred embodiments, the pharmaceutically active compounds are ansamycins, pharmaceutically acceptable salts, or prodrugs thereof.
Claims76
A pharmaceutical formulation for oral administration comprising a pharmacutically effective amount of an ansamycin and one or more pharmaceutically acceptable solubilizers, with the proviso that when the solubilizer is a phospholipid, it is present in a concentration of at least 5% w/w of the formulation.
An oral pharmaceutical composition comprising a pharmaceutically effective amount of an ansamycin and one or more excipients, wherein at least one of the excipients is a phospholipid present in a total concentration of at least 5% w/w of the composition.
An oral pharmaceutical composition comprising a pharmaceutically effective amount of an ansamycin and one or more excipients, wherein at least one of said excipients is a non-phospholipid solublizer.
An oral pharmaceutical composition comprising a pharmaceutical effective amount of a low melt 17-AAG and one or more pharmaceutically acceptable excipients and optionally co-solvents.
Dependencies are inferred from the claim text.