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US 2006/0067952 A1Published application
Low oil emulsion compositions for delivering taxoids and other insoluble drugs
AssigneeSD Pharmaceuticals, Inc.
InventorAndrew Chen
Life of this patent
Estimating the term…
Abstract
The present invention provides injectable oil-in-water emulsions of taxoid drugs or other water insoluble drugs. The present invention also provides methods for preparing and using such oil-in-water emulsions.
Claims47
An injectable oil-in-water emulsion comprising:
- (a) a taxoid drug at a concentration of at least about 0.03% by weight,
- (b) an oil component at a concentration of at most about 6% by weight, wherein the oil component comprises a vegetable oil,
- (c) a phospholipid component at a concentration between about 1.2% to about 5% by weight, and
- (d) water.
1 more element
An injectable oil-in-water emulsion comprising:
- (a) a taxoid drug at a concentration of about 0.03% or higher by weight,
- (b) medium chain triglyceride at a concentration of about 1% to about 3% by weight,
- (c) soybean oil at a concentration of about 1% to about 3% by weight,
- (d) soy lecithin or egg lecithin at a concentration of about 1% to about 5% by weight,
- (e) glycine at a concentration of about 0.5 to 1% by weight,
- (f) glycerol at a concentration of about 1.5 to 2.5% by weight,
- (g) optionally EDTA at a concentration of about 0.005% by weight, and
- (h) water.
5 more elements
An injectable oil-in-water emulsion comprising:
- (a) docetaxel at a concentration of about 0.05% by weight,
- (b) medium chain triglyceride at a concentration of about 1% to about 3% by weight,
- (c) soybean oil at a concentration of about 1% to about 3% by weight,
- (d) soy lecithin or egg lecithin at a concentration of about 1% to about 5% by weight,
- (e) glycine at a concentration of about 0.5 to 1% by weight,
- (f) glycerol at a concentration of about 1.5 to 2.5% by weight,
- (g) optionally EDTA at a concentration of about 0.005% by weight,
- (h) sodium chloride and/or hydrochloric acid to adjust pH to about 3.5 and 7.0, and
- (i) water.
6 more elements
An injectable oil-in-water emulsion comprising:
- (a) paclitaxel at a concentration of about 0.05% by weight,
- (b) medium chain triglyceride at a concentration of about 1% to about 3% by weight,
- (c) soybean oil at a concentration of about 1% to about 3% by weight,
- (d) soy lecithin or egg lecithin at a concentration of about 1% to about 5% by weight,
- (e) glycine at a concentration of about 0.5 to 1% by weight,
- (f) glycerol at a concentration of about 1.5 to 2.5% by weight,
- (g) optionally EDTA at a concentration of about 0.005% by weight,
- (h) sodium chloride and/or hydrochloric acid to adjust pH to about 6 and 7, and
- (i) water.
6 more elements
An injectable oil-in-water emulsion comprising:
- (a) docetaxel at a concentration of about 0.05% by weight,
- (b) soybean oil at a concentration of about 1% to about 6% by weight,
- (c) soy lecithin or egg lecithin at a concentration of about 1% to about 5% by weight,
- (d) glycine at a concentration of about 0.5 to 1% by weight,
- (e) glycerol at a concentration of about 1.5 to 2.5% by weight,
- (f) optionally EDTA at a concentration of about 0.005% by weight,
- (g) sodium chloride and/or hydrochloric acid to adjust pH to about 3.5 and 7.0 by weight, and
- (h) water.
5 more elements
An injectable oil-in-water emulsion comprising:
- (a) paclitaxel at a concentration of about 0.05% by weight,
- (b) soybean oil at a concentration of about 1% to about 6% by weight,
- (c) soy lecithin or egg lecithin at a concentration of about 1% to about 5% by weight,
- (d) glycine at a concentration of about 0.5 to 1% by weight,
- (e) glycerol at a concentration of about 1.5 to 2.5% by weight,
- (f) optionally EDTA at a concentration of about 0.005% by weight,
- (g) sodium chloride and/or hydrochloric acid to adjust pH to about 6 and 7, and
- (h) water.
5 more elements
Dependencies are inferred from the claim text.