Method and composition for inhibiting reperfusion injury in the brain
AssigneeBoard of Regents of the University of Nebraska
InventorsVinod Labhasetwar, Maram Reddy
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Abstract
The present invention relates to a method for inhibiting reperfusion injury in the brain. The method involve injecting via the carotid artery or jugular vein an antioxidant-loaded nanoparticle. A nanoparticle formulation containing an inert plasticizer is also provided for sustained release of an active agent.
Claims14
A method for inhibiting reperfusion injury in the brain comprising administering an effective amount of an antioxidant, wherein said antioxidant is formulated in a nanoparticle and administered via the carotid artery or jugular vein to a subject in need of treatment, thereby inhibiting reperfusion injury in the brain of said subject.
The method of claim 2, wherein the small molecule antioxidant comprises a vitamin antioxidant, acetyl salicyclic acid, mannitol, captopril, arginine, or pyruvate. 5. The method of claim 4, wherein the vitamin antioxidant comprises lycopene, lutein, xeaxanthine, Vitamin A, carotene, Vitamin C, tocopherol, or prodrugs or pharmaceutically acceptable salts thereof.
A composition for sustained release of an effective amount of an active agent said composition comprising an active agent, at least one biodegradable polymer, and an inert plasticizer.
Dependencies are inferred from the claim text.