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AssigneeThe University of North Carolina at Chapel Hill
InventorsJenny Ting, Michael Linhoff, Jonathan Harton, Kristi Williams, John Lich, William O'Connor, Christopher Moore, Beckly Davis, Willie Brickey, Brian Conti, Jinghua Zhang, Xin-Sheng Zhu
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The present invention relates to a new family of structurally and functionally related nucleic acids and proteins, designed the CATERPILLER family, which is characterized by landmark structural motifs including a nucleotide binding domain and leucine-rich repeat domains.
An isolated nucleic acid encoding a polypeptide selected from the group consisting of:
An isolated nucleic acid encoding a functional fragment of a CIAS1 polypeptide.
A method of modulating the cellular activity of a polypeptide selected from the group consisting of Monarch-1, CIAS1, CATERPILLER 11.2, CATERPILLER 11.3, CATERPILLER 16.1, CATERPILLER 16.2, and a functional fragment thereof, comprising introducing into a cell a compound that modulates the activity of the polypeptide in an amount effective to modulate the activity of the polypeptide in the cell.
A method of modulating cellular inflammatory responses, comprising introducing into a cell a compound that modulates the activity of a polypeptide selected from the group consisting of Monarch-1, CIAS1, CATERPILLER 11.2, CATERPILLER 11.3, CATERPILLER 16.1, CATERPILLER 16.2, and a functional fragment thereof, said compound introduced in an amount effective to modulate cellular inflammatory responses.
A method of modulating apoptosis, comprising introducing into a cell a compound that modulates the activity of a polypeptide selected from the group consisting of Monarch-1, CIAS1, CATERPILLER 11.2, CATERPILLER 11.3, CATERPILLER 16.1, CATERPILLER 16.2, and a functional fragment thereof, said compound introduced in an amount effective to modulate apoptosis.
A method of modulating Toll-like receptor activity, comprising introducing into a cell a compound that modulates the activity of a polypeptide selected from the group consisting of Monarch-1, CIAS1, CATERPILLER 11.2, CATERPILLER 11.3, CATERPILLER 16.1, CATERPILLER 16.2, and a functional fragment thereof, said compound introduced in an amount effective to modulate Toll-like receptor activity.
A method of identifying a compound that binds to a polypeptide selected from the group consisting of Monarch-1, CATERPILLER 11.2, CATERPILLER 11.3, CATERPILLER 16.1, CATERPILLER 16.2, and a functional fragment of any of the foregoing, comprising:
A method of identifying a compound that modulates the activity of a polypeptide selected from the group consisting of Monarch-1, CATERPILLER 11.2, CATERPILLER 11.3, CATERPILLER 16.1, CATERPILLER 16.2, and a functional fragment of any of the foregoing, comprising:
A method of identifying a compound that can modulate inflammatory responses, comprising:
A method of identifying a compound that can modulate apoptosis, comprising:
A method of identifying a compound that can modulate the Toll-like receptor pathway, comprising:
Dependencies are inferred from the claim text.