Isoindoline derivative

A compound represented by formula (I):

• wherein R1s are the sane or different 2 groups, each of them is selected from the group consisting of C1-3 alkyl;
• or when R1s are two adjacent groups, the two R1s taken together may form a saturated 5- or 6-membered cyclic group which may have 1 or 2 hetero atoms selected from the group consisting of sulfur, nitrogen and oxygen:
• X is oxygen or sulfur:
• R2 is selected from the group consisting of phenyl, benzyl, pyridyl, pyridylmethyl, pyrimidinyl, cyclohexyl, methylpiperazinyl, indanyl, 1,3-benzodioxolyl and naphthyl, all of which may optionally be substituted;
• provided that when R2 is phenyl, the 3- and 4-positions of the phenyl moiety are not substituted by alkoxy groups at the same time:
• represents a single bond or double bond:
• and
• L is
• —(CH2)n—H
• wherein n is an integer of 1-8;
• wherein R3 is selected from the group consisting of hydrogen, linear or branched C1-8 alkyl, C1-3 alkyl substituted by at least one fluorine atoms, cyclopentyl, cyclohexyl, cycloheptyl, cyclohexylmethyl, benzyl, 2-pyridyl and 2-pyrimidinyl groups, n′ is an integer of 1-3;
• wherein W is oxygen or sulfur atom, A is selected from the group consisting of linear or branched C1-5 alkyl, 2-dimethylaminoethylamino, 2-thiazolylamino, 4-methylhomopiperazinyl, 4-piperidinopiperidino, dimethylaminoanilino, pyridylamino, piperidino, 4-ethoxycarbonyl piperidino, 4-carboxypiperidino and a group represented by formula (J)
• wherein R3 is as defined above,
• n″ is an integer of 0-3;
• wherein E is selected from the group consisting of hydrogen, linear or branched C1-6 alkyl or alkenyl, C1-3 alkyl substituted by at least one fluorine atoms, 2-methoxyethyl, 2-methylthioethyl, 2-dimethylaminoethyl, phenyl, pyridyl, benzyl, pyridylmethyl, cyclopentyl, cyclohexyl, tetrahydro-2H-pyranyl, cyclohexylmethyl, 1-methyl-4-piperidyl indanyl, 1,3-benzodioxolyl and 1H-indolyl, wherein phenyl and pyridyl may optionally be substituted by the group consisting of halogen, methyl, methoxy, isopropyl and allyl, and n″ is an interger of 0-3;
• —(CH2)n′-T-G
• wherein T is oxygen, sulfur or NH, G is selected from the group consisting of hydrogen, linear or branched C1-5 alkyl, C1-3 alkyl substituted by at least one fluorine atoms, 2-methoxyethyl and alkylcarbonyl, n′ is an integer of 1-3;
• wherein R3 is as defined above;
• wherein E is as defined above;
• wherein R3 is as defined above;
• or
• wherein E is as defined above
• or a salt thereof.