Amino-tetrazole analogues and methods of use

A compound having Formula (I) or Formula (II),

• or a therapeutically acceptable salt, solvate, prodrug, or salt of a prodrug thereof, in which
• R2 is phenyl or pyridyl, wherein each R2 is substituted with one, two, three, four, or five substituents independently selected from the group consisting of —Cl, —F, —Br, —I, —NH2, —R2a, —OR2a, —NHR2a, —N(R2a)2, —CN, —SR2a, and —SO2R2a;
• R2a is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, —C6-alkyl, or R2b;
• R2b is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl, each of which is substituted with one or two or three substituents independently selected from the group consisting of —Br, —I, —F, —Cl, —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —NH2, —NHR2c, —N(R2c)2, —CN, —SR2c, and —SO2R2c;
• R2c is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl;
• m is 0, 1, 2, or 3;
• X and Y are independently selected from the group consisting of —H, —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, and C6-alkyl;
• or
• X and Y together with the carbon atom to which they are attached form a ring selected from the group consisting of cyclopropane, cyclobutane, cyclopentane, cyclohexane, tetrahydrofuran, tetrahydrothiophene, pyrrolidine, dioxolane, tetrahydropyran, piperidine, morpholine, thiomorpholine, and piperazine, each or which is unsubstituted or substituted with one, two, three, or four substituents independently selected from the group consisting of —Cl, —F, —Br, —I, —NH2, —R2a, —OR2a, —NHR2a, —N(R2a)2, —CN, —SR2a, and —SO2R2a;
• Z is —H, —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl;
• or
• Z and X together with the atoms to which they are attached form a ring selected from the group consisting of pyrrolidine, piperidine, morpholine, thiomorpholine, and piperazine;
• R1 is
• proximal phenyl which is unfused or fused with a distal cyclopentane, cyclohexane, cyclopentene, cyclohexene, dioxane, dioxolane, naphthalene, benzene, furan, imidazole, isothiazole, oxazole, isoxazole, pyrazine, pyrazole, pyridazine, pyridine, pyrimidine, pyrrole, tetrahydrofuran, tetrahydrothiophene, thiazole, thiophene, pyrrolidine, dioxolane, pyrazolidine, pyran, piperidine, morpholine, thiomorpholine, oxazolidinone, morpholinone, or piperazine ring, in which the proximal phenyl ring and the distal ring are, independently of each other, unsubstituted or substituted with one, two, three, or four substituents independently selected from the group consisting of —Cl, —F, —Br, —I, —NO2, —OH, —NH2, —R1a, —OR1a, —NHR1a, —N(R1a)2, —CN, —SR1a, —SO2R1a, —SO2NH2, —SO2N(H)(R1a), —SO2N(R1a)2, —C(O)R1d, —C(O)OH, —C(O)OR1a, —C(O)NH2, —C(O)N(H)(R1a), —C(O)N(R1a)2, —OR1e, —SR1e, —SO2R1e, —SO2N(H)(R1e), —SO2N(R1d)(R1e), —NH(R1e), —N(R1d)(R1e), —NHC(O)R1f, —N(R1d)C(O)R1f and —R1c;
• proximal isoxazolyl, oxazolyl, pyrrolidinyl, pyridyl, thienyl, pyrrolyl, pyridazinyl, pyrazolyl, imidazolyl, thiazolyl, furyl, tetrahydrofuryl, tetrahydropyranyl, pyrimidinyl, pyrazinyl, or imidazopyridinyl, each of which is unfused or fused with a distal cyclopentane, cyclohexane, cyclopentene, cyclohexene, naphthalene, benzene, furan, imidazole, isothiazole, oxazole, isoxazole, pyrazine, pyrazole, pyridazine, pyridine, pyrimidine, pyrrole, tetrahydrofuran, tetrahydrothiophene, thiazole, thiophene, pyrrolidine, dioxolane, pyrazolidine, pyran, piperidine, morpholine, thiomorpholine, or piperazine ring, in which the proximal pyrrolidinyl, pyridyl, thienyl, pyrrolyl, pyridazinyl, pyrazolyl, imidazolyl, thiazolyl, furyl, tetrahydrofuryl, pyrimidinyl, pyrazinyl, or imidazopyridinyl ring and the distal ring are, independently of each other, unsubstituted or substituted with one, two, three, or four substitutents independently selected from the group consisting of of —Cl, —F, —Br, —I, —NO2, —OH, —NH2, —R1a, OR1a, —NHR1a, —N(R1a)2, —CN, —SR1a, —SO2R1a, —SO2NH2, —SO2N(H)(R1a), —SO2N(R1a)2, —C(O)R1a, —C(O)OH, —C(O)OR1a, —C(O)NH2, —C(O)N(H)(R1a), —C(O)N(R1a)2, —OR1e, —SR1e, —SO2R1e, —SO2N(H)(R1e), —SO2N(R1d)(R1e), —NH(R1e), —N(R1d)(R1e), —NHC(O)R1f, —N(R1d)C(O)R1f, and —R1c;
• proximal bicyclo[2,2,1]heptyl, cyclopentyl, cyclohexyl, cyclopentenyl, or cyclohexenyl, each of which is unfused or fused with a distal cyclopentane, cyclohexane, cyclopentene, cyclohexene, naphthalene, benzene, furan, imidazole, isothiazole, oxazole, isoxazole, pyrazine, pyrazole, pyridazine, pyridine, pyrimidine, pyrrole, imidazoline, tetrahydrofuran, tetrahydrothiophene, thiazole, thiophene, pyrrolidine, dioxolane, pyrazoline, pyrazolidine, pyran, piperidine, morpholine, thiomorpholine, or piperazine ring, in which the proximal cyclopentyl, cyclohexyl, cyclopentenyl, or cyclohexenyl ring and the distal ring are, independently of each other, unsubstituted or substituted with one, two, three, or four substituents independently selected from the group consisting of ═O, —Cl, —F, —Br, —I, —NO2, —OH, —NH2, —R1a, —OR1a, —NHR1a, —N(R1a)2, —CN, —SR1a, —SO2R1a, —SO2NH2, —SO2N(H)(R1a), —SO2N(R1a)2, —C(O)R1a, —C(O)OH, —C(O)OR1a, —C(O)NH2, —C(O)N(H)(R1a), —C(O)N(R1a)2, —OR1e, —SR1e, —SO2R1e, —SO2N(H)(R1e), —SO2N(R1d)(R1e), —NH(R1e), —N(R1d)(R1e), —NHC(O)R1f, —N(R1d)C(O)R1f, and —R1c;
• admantyl unsubstituted or substituted with one, two, three, or four substituents independently selected from the group consisting of —Cl, —F, —Br, —I, —NO2, —OH, —NH2, —R1d, —OR1d, —NHR1d, —N(R1d)2, —CN, —SR1d, —SO2R1d, —SO2NH2, —SO2N(H)(R1d), —SO2N(R1d)2, —C(O)R1d, —COOH, —C(O)OR1d, —C(O)NH2, —C(O)N(H)(R1d), and —C(O)N(R1s)2;
• or
• 2,3-dihydrospiroindene-1,4′-piperidinyl unsubstituted or substituted with one, two, three, or four substituents independently selected from the group consisting of —Cl, —F, —Br, —I, —NO2, —OH, —NH2, —R1d, —OR1d, —NHR1d, —N(R1d)2, —CN, —SR1d, —SO2R1d, —SO2NH2, —SO2N(H)(R1d), —SO2N(R1d)2, —C(O)R1d, —COOH, —C(O)OR1d, —C(O)NH2, —C(O)N(H)(R1d), and —C(O)N(R1d)2;
• R1a is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, —C6-alkyl, or —R1b;
• R1b is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl, each of which is substituted with one or two or three substituents independently selected from the group consisting of —F, —Cl, —Br, —I, —NH2, —OH, —OR1d-l , —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, —C6-alkyl, —R1c, —N(R1d)2, and —NHR1d;
• R1c is cyclopentyl, cyclohexyl, cyclopentenyl, cyclohexenyl, azetidinyl, naphthyl, quninolinyl, isoquinolinyl, phenyl, furyl, imidazolyl, isothiazolyl, oxazolyl, oxazolinyl, isoxazolyl, pyrazinyl, pyrazolyl, pyridazinyl, pyridyl, pyrimidinyl, pyrrolyl, imidazolinyl, tetrahydrofuryl, tetrahydrothienyl thiazolyl, thienyl, pyrrolidinyl, dioxolanyl, pyrazolinyl, pyrazolidinyl, pyranyl, piperidyl, morpholinyl, thiomorpholinyl, piperazinyl, 2-azabicyclo[2.2.2]octyl, 2-oxa-5-azabicyclo[2.2.2]octyl, 2,5-diazabicyclo[2.2.2]octyl, 2-azabicyclo[2.2.1]heptyl, 2-oxa-5-azabicyclo[2.2.1]heptyl, 2,5-diazabicyclo[2.2.1]heptyl, 2-azabicyclo[2.1.1]hexyl, 5-azabicyclo[2.1.1]hexyl, 3-azabicyclo[3.2.0]heptyl, 3,6-diazabicyclo[3.2.0]heptyl, octahydrocyclopenta[c]pyrrolyl, hexahydro-1H-furo[3,4-c]pyrrolyl, octahydropyrrolo[3,4-c]pyrrolyl, 3-azabicyclo[3.1.1]heptyl, 6-oxa-3-azabicyclo[3.1.1]heptyl, octahydro-1H-4,7-methanoisoindolyl, octahydro-1H-4,7-epoxyisoindolyl, 8-azabicyclo[3.2.1]octyl, 3-oxa-8-azabicyclo[3.2.1]octyl, 1,4-diazepanyl, 1,4-diazabicyclo[3.2.2]nonyl, 1,4-diazatricyclo[4.3.1.13,8]undecyl, 3,10-diazabicyclo[4.3.1]decyl, or 8-oxa-3-azabicyclo[3.2.1]octyl, each of which is unsubstituted or substituted with one, two, three, or four substituents independently selected from the group consisting of —Cl, —F, —Br, —I, ═O, —NO2, —CN, —OH, —R1aa, —NH2, —OR1aa, —SR1aa, —NHR1aa, —N(R1aa)2, —C(O)R1aa, S(O)2R1aa, S(O)2NH2, S(O)2N(R1aa)2, —C(O)NH2, —C(O)N(H)(R1aa), —C(O)N(R1aa)2, —C(O)OH, —C(O)OR1aa, —OR1h, —N(H)R1h), —N(R1d)(R1h) and —R1h;
• R1aa is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, —C6-alkyl, or —R1bb;
• R1bb is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl, each of which is substituted with one or two or three substituents independently selected from the group consisting of —F, —Cl, —Br, —I, —NO2, —CN, haloalkyl, haloalkoxy, —NH2, —OH, —OR1d, —SR1d, —S(O)2R1d, —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, —C6-alkyl, —N(R1d)2, —NHR1d;
• —C(O)OH, —C(O)OR1d, —C(O)NH2, —C(O)N(H)(R1d), —C(O)N(R1d)2, —S(O)2NH2, —S(O)2N(H)(R1d), —S(O)2N(R1d)2 and —R1h;
• R1d is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl;
• R1e is phenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrrolyl, furyl, thienyl, imidazolyl, thiazolyl, pyrrolidinyl, piperidyl, azepinyl, tetrahydrofuryl, tetrahydropyranyl or oxazolyl;
• wherein, each R1e is unsubstituted or substituted with one, two, three or four substituents independently selected from the group consisting of ═O, —Cl, —F, —Br, —I, —NO2, —CN, —OH, —R1aa, —OR1aa, —SR1aa, —NH2, —NHR1aa, and —N(R1aa)2;
• R1f is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, —C6-alkyl, aryl, heteroaryl, —R1h, or R1g;
• R1g is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl, each of which is substituted with one substituent selected from the group consisting of aryl and heteroaryl;
• R1h is cycloalkyl, cycloalkenyl, aryl, heteroaryl or heterocycle, in which each R1h is unsubstituted or substituted with one or two or three or four or five substituents independently selected from the group consisting of —F, —Cl, —Br, —I, —NO2, —CN, haloalkyl, haloalkoxy, —NH2, —OH, —OR1d, —SR1d, —S(O)2R1d, —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, —C6-alkyl, —N(R1d)2, —NHR1d, —C(O)OH, —C(O)OR1d, —C(O)NH2, —C(O)N(H)(R1d), —C(O)N(R1d)2, —S(O)2NH2, —S(O)2N(H)(R1d), and —S(O)2N(R1d)2;
• provided that when R1 is proximal phenyl fused with a distal pyrrole, thiophene, furan, pyrazole, isoxazole, or isothiazole ring, the distal pyrrole, thiophene, furan, pyrazole, isoxazole, or isothiazole ring is not substituted with —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, —C6-alkyl, pyrrolidinyl, piperidyl, —C1-alkyl substituted with pyrrolidinyl or piperidyl, —C2-alkyl substituted with —N(R1d)2, —NH2, or —NHR1d, —C3-alkyl substituted with —N(R1d)2, —NH2, or —NHR1d, —C4-alkyl substituted with —N(R1d)2, —NH2, or —NHR1d, —C5-alkyl substituted with —N(R1d)2, —NH2, or —NHR1d, or —C6-alkyl substituted with —N(R1d)2, —NH2, or —NHR1d;
• and provided that when m is 0 and R2 is phenyl, then R1 is not proximal unfused phenyl;
• A is N or CR6;
• B is N or CR7;
• E is N or CR8;
• provided that only one of A, B and E is N;
• R3 is —NH2, —R3a, —OR3a, —NHR3a, —N(R3a)2, —NHC(O)R3f, —N(R3d)C(O)R3f, —R3c, —OR3e, —SR3e, —NH(R3e), or —N(R3d)(R3e);
• R3a is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, —C6-alkyl, or R3b;
• R3b is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl, each of which is substituted with one or two or three substituents independently selected from the group consisting of —NH2, —CN, —OH, —OR3d, —R3c, —N(R3d)2, and —NHR3d;
• R3c is cyclopentyl, cyclohexyl, cyclopentenyl, cyclohexenyl, azetidinyl, naphthyl, quninolinyl, isoquinolinyl, phenyl, furyl, imidazolyl, isothiazolyl, oxazolyl, oxazolinyl, isoxazolyl, pyrazinyl, pyrazolyl, pyridazinyl, pyridyl, pyrimidinyl, pyrrolyl, imidazolinyl, tetrahydrofuryl, tetrahydrothienyl thiazolyl, thienyl, pyrrolidinyl, dioxolanyl, pyrazolinyl, pyrazolidinyl, pyranyl, piperidyl, morpholinyl, thiomorpholinyl, piperazinyl, 2-azabicyclo[2.2.2]octyl, 2-oxa-5-azabicyclo[2.2.2]octyl, 2,5-diazabicyclo[2.2.2]octyl, 2-azabicyclo[2.2.1 ]heptyl, 2-oxa-5-azabicyclo[2.2.1]heptyl, 2,5-diazabicyclo[2.2.1]heptyl, 2-azabicyclo[2.1.1]hexyl, 5-azabicyclo[2.1.1]hexyl, 3-azabicyclo[3.2 .0]heptyl, 3,6-diazabicyclo[3.2.0]heptyl, octahydrocyclopenta[c]pyrrolyl, hexahydro-1H-furo[3,4-c]pyrrolyl, octahydropyrrolo[3,4-c]pyrrolyl, 3-azabicyclo[3.1.1]heptyl, 6-oxa-3-azabicyclo[3.1.1]heptyl, octahydro-1H-4,7-methanoisoindolyl, octahydro-1H-4,7-epoxyisoindolyl, 8-azabicyclo[3.2.1]octyl, 3-oxa-8-azabicyclo[3.2.1]octyl, 1,4-diazepanyl, 1,4-diazabicyclo[3.2.2]nonyl, 1,4-diazatricyclo[4.3.1.13,8]undecyl, 3,10-diazabicyclo[4.3.1]decyl, or 8-oxa-3-azabicyclo[3.2.1]octyl, in which each ring is unsubstituted or substituted with one, two, three, or four substituents independently selected from the group consisting of —Cl, —F, —Br, —I, —OH, —R3aa, —NH2, —OR3aa, —SR3aa, —NHR3aa, and —N(R3aa)2;
• R1d is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl;
• R3aa is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, —C6-alkyl, or —R3bb;
• R3bb is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl, each of which is substituted with one or two or three substituents independently selected from the group consisting of —F, —Cl, —Br, —I, —NH2, —OH, —OR3d, —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, —C6-alkyl, —N(R3d)2, and —NHR3d;
• R3e is phenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrrolyl, furyl, thienyl, imidazolyl, thiazolyl, pyrrolidinyl, piperidyl, azepinyl, tetrahydrofuryl, tetrahydropyranyl or oxazolyl;
• wherein each R3e is unsubstituted or substituted with one, two, three or four substituents independently selected from the group consisting of ═O, —Cl, —F, —Br, —I, —OH, —R3aa, —OR3aa, —SR3aa, —NH2, —NHR3aa, and —N(R3aa)2;
• R3f is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, —C6-alkyl, aryl, heteroaryl, or R3g;
• R3g is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl, each of which is substituted with one substituent selected from the group consisting of aryl and heteroaryl;
• v is one, two, or three, and when v is two or three, R3 may be the same or different;
• R4 is —Cl, —F, —Br, —I, —NH2, —R4a, —OR4a, —NHR4a, —N(R4a)2, —CN, —SR4a, or —SO2R4a;
• R4a is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, —C6-alkyl, or R4b;
• R4b is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl, each of which is substituted with one or two or three substituents independently selected from the group consisting of —Br, —I, —F, —Cl, —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —NH2, —NHR4c, —N(R4c)2, —CN, —SR4c, and —SO2R4c;
• R4c is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl;
• R5 is —H, —Cl, —F, —Br, —I, —NH2, —R5a, —OR5a, —NHR5a, —N(R5a)2, —CN, —SR5a, or —SO2R5a;
• R5a is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, —C6-alkyl, or R5b;
• R5b is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl, each of which is substituted with one or two or three substituents independently selected from the group consisting of —Br, —I, —F, —Cl, —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —NH2, —NHR5c, —N(R5c)2, —CN, —SR5c, and —SO2R5c;
• R5c is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl;
• R6 is —H, —Cl, —F, —Br, —I, —NH2, —R6a, —OR6a, —NHR6a, —N(R6a)2, —CN, —SR6a, or —SO2R6a;
• R6a is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, —C6-alkyl, or R6b;
• R6b is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl, each of which is substituted with one or two or three substituents independently selected from the group consisting of —Br, —I, —F, —Cl, —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —NH2, —NHR6c, —N(R6c)2, —CN, —SR6c, and —SO2R6c;
• R6c is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl;
• R7 is —H, —Cl, —F, —Br, —I, —NH2, —R7a, —OR7a, —NHR7a, —N(R7a)2, —CN, —SR7a, or —SO2R7a;
• R7a is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, —C6-alkyl, or R7b;
• R7b is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl, each of which is substituted with one or two or three substituents independently selected from the group consisting of —Br, —I, —F, —Cl, —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —NH2, —NHR7c, —N(R7c)2, —CN, —SR7c, and —SO2R7c;
• R7c is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl;
• R8 is —H, —Cl, —F, —Br, —I, —NH2, —R8a, —OR8a, —NHR8a, —N(R8a)2, —CN, —SR8a, or —SO2R8a;
• R8a is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, —C6-alkyl, or R8b;
• R8b is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl, each of which is substituted with one or two or three substituents independently selected from the group consisting of —Br, —I, —F, —Cl, —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —NH2, —NHR8c, —N(R8c)2, —CN, —SR8c, and —SO2R8c;
• R8c is —C1-alkyl, —C2-alkyl, —C3-alkyl, —C4-alkyl, —C5-alkyl, or —C6-alkyl;
• and
• with the proviso that the following compounds are excluded:
• N-benzyl-1-(4-methoxyphenyl)-1H-tetraazol-5-amine;
• N,1-bis(4-methylphenyl)-1H-tetraazol-5-amine;
• N,1-bis(4-methoxyphenyl)-1H-tetraazol-5-amine;
• and
• N,1-bis(2,4-dimethylphenyl)-1H-tetraazol-5-amine.