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US 2006/0052369 A1Published application
Compositions and methods relating to novel compounds and targets thereof
AssigneeThe Regents of the University of Michigan
InventorGary Glick
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Abstract
The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.
Claims31
A composition comprising the following formula:
- including both R and S enantiomeric forms and racemic mixtures;
- wherein R1 comprises a chemical moiety comprising a hydrogen bonding donor;
- and R2 comprises a hydrophobic chemical moiety.
A method of treating cells, comprising:
- a. providing
- i) target cells;
- and
- ii) a composition comprising the following formula:
- including both R and S enantiomeric forms and racemic mixtures;
- wherein R1 comprises a chemical moiety comprising a hydrogen bonding proton donor;
- wherein R2 comprises a hydrophobic chemical moiety;
- and
- b) exposing said target cells to said composition under conditions such that said composition binds to said mitochondria so as to increase superoxide levels or alter cellular ATP levels in said cells.
6 more elements
Dependencies are inferred from the claim text.