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US 2006/0051440 A1Published application
Factors that bind intestinal toxins
OwnerJoel Moss, Masatoshi Nodainventors
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OwnerJoel Moss, Masatoshi Nodainventors
Estimating the term…
Methods for neutralizing bacterial toxins such as Shiga toxins and cholera toxins are disclosed. In a particular embodiment, a method is provided for treating a subject suffering from an infection caused by an Stx-producing organism by administering a therapeutically effective amount of a hop bract tannin obtained from Humulus lupulus. Also provided are methods for isolating polyphenolic compounds that bind Stx molecules, and methods for detecting the presence of Stx molecules in a biological sample. In a disclosed embodiment, a subject infected with a Shiga toxin-producing E. coli strain is treated by enterically administering a high molecular weight fraction of hop bract extract to the subject.
A method for treating a subject having an infection caused by an Stx-producing organism by administering to the subject a therapeutically effective amount of hop bract tannin.
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25-26. (canceled)
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A method for detecting the presence of an Stx in a biological sample, comprising:
A method for isolating and purifying Stx-binding polyphenols, comprising:
A method for prophylatic or post-exposure treatment of an inhaled Stx comprising administering a therapeutically effective amount of hop bract tannin intranasally to a subject.
A biosensor, comprising:
47-57. (canceled)
A method for neutralizing a bacterial toxin, comprising:
An isolated polyphenolic component of a high molecular weight fraction of a hop bract extract, the high molecular weight fraction having a weight average molecular weight of greater than 5 kDa.
A subfraction of a high molecular weight fraction of a hop bract extract, the high molecular weight fraction having a weight average molecular weight of greater than 5 kDa.
Dependencies are inferred from the claim text.