Modified release formulations of memantine oral dosage forms

A modified release solid oral dosage form, comprising

• (a) between about 2.5% w/w and about 20.0% w/w of memantine hydrochloride;
• (b) between about 68% w/w and about 77% w/w of hydroxypropyl methyl cellulose;
• (c) between about 6.9% w/w and about 15% w/w of lactose monohydrate;
• (d) between about 0.8% w/w and about 1.3% w/w of fumed silica;
• (e) between about 3.0% w/w and about 5.0% w/w of talc;
• and
• (f) between about 0.9% w/w and about 1.1% w/w of magnesium stearate;
• wherein the dissolution rate of memantine hydrochloride of more than about 80% is achieved after about 12 hours.

A modified release solid oral dosage form, comprising:

• (a) between about 5% w/w and about 35% w/w of memantine hydrochloride;
• (b) between about 54% w/w and about 65% w/w of hydroxypropyl methyl cellulose;
• (c) between about 7% w/w and about 24% w/w of lactose monohydrate;
• (d) between about 0.8% w/w and about 1.3% w/w of fumed silica;
• (e) between about 3.0% w/w and about 5.0% w/w of talc;
• and
• (f) between about 0.4% w/w and about 0.6% w/w of magnesium stearate;
• wherein the dissolution rate of memantine hydrochloride of more than about 80% is achieved after about 6 hours.

A modified release solid oral dosage form, comprising:

• (a) between about 5% w/w and about 35% w/w of memantine hydrochloride;
• (b) between about 54% w/w and about 65% w/w of hydroxypropyl methyl cellulose;
• (c) between about 7% w/w and 40% w/w of microcrystalline cellulose;
• (d) between about 0.8% w/w and about 1.3% w/w of fumed silica;
• (e) between about 3.0% w/w and about 5.0% w/w of talc;
• and
• (f) between about 0.4% w/w and about 0.6% w/w of magnesium stearate;
• wherein the dissolution rate of memantine hydrochloride of more than about 80% is achieved after about 6 hours.

A modified release solid oral dosage form, comprising:

• (a) between about 5% w/w and about 35% w/w of memantine hydrochloride;
• (b) between about 54% w/w and about 65% w/w of hydroxypropyl methyl cellulose;
• (c) between about 7% w/w and 40% w/w of dicalcium phosphate;
• (d) between about 0.8% w/w and about 1.3% w/w of fumed silica;
• (e) between about 3.0% w/w and about 5.0% w/w of talc;
• and
• (f) between about 0.4% w/w and about 0.6% w/w of magnesium stearate;
• wherein the dissolution rate of memantine hydrochloride of more than about 80% is achieved after about 6 hours.