Method of enhancing absorptions of transmucosal administration formulations
OwnerSing Chow, Yan-feng Wang +1inventors
InventorsSing Chow, Yan-feng Wang, Zhong Zuo
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Abstract
Disclosed is a method for enhancing absorption of a medicament that is suitable for administering transmucosally to a subject by providing an environment of the administration with a suitable pH. A medicament of propranolol suitably administered sublingually is provided. The medicament of propranolol can be used for treating cardiovascular diseases.
Claims25
A method for enhancing absorption of a medicament that is suitable for transmucosal administration to a subject, said method comprising providing an environment for the administration with a pH of about:
- pH
- =
- -
- log
-
- (
- Ka
- ·
- S
- i
- S
- u
- )
- in which Ka is the ionization constant (dissociation constant) of the compound in water, Si is the solubility of the ionized form of the compound, and Su is the solubility of the non-ionized form of the compound.
A method for enhancing absorption of a medicament comprising propranolol or a pharmaceutically acceptable form thereof that is administered transmucosally to a subject, comprising providing an environment for the administration with a pH in the range from about 7.2 to about 7.8.
A medicament suitable for transmucosal administration to a subject, comprising an effective amount of propranolol or a pharmaceutically acceptable form thereof, and a pharmaceutically acceptable carrier, wherein the medicament provides an environment of the administration with a pH of about 7.2 to about 7.8.
A method for treating cardiovascular diseases of a subject comprising transmucosal administration of a therapeutically effective amount of propanolol to the subject in an environment with a pH range of about 7.2 to about 7.8.
Dependencies are inferred from the claim text.