Methods and compositions for the targeting of a systemic immune response to specific organs or tissues
AssigneeThe Johns Hopkins University
InventorsRichard Schulick, Drew Pardoll, Ajay Jain
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AssigneeThe Johns Hopkins University
InventorsRichard Schulick, Drew Pardoll, Ajay Jain
Estimating the term…
The invention provides methods and compositions for targeting a separately generated immune response to a specific organ or tissue, e.g. one affected by cancer, using one or more agents with a tropism for the organ or tissue or that can be specifically localized to the desired organ or tissue. For example, the invention provides methods ands compositions for treating liver metastases from colorectal cancer using a combination of a granulocyte/macrophage colony stimulating factor (GM-CSF) augmented tumor cell vaccination and Listeria monocytogenes (LM) infection.
1) A method of generating a systemic immune response against an organ or tissue-specific disease or condition in a subject comprising:
18) A method of treating a tumor or cancerous growth localized to a tissue or organ in a subject comprising:
21) A formulation for generating a systemic immune response against an organ or tissue-specific disease or condition in a subject comprising a therapeutically effective amount of a vaccine which generates an immune response against the organ or tissue-specific disease or condition;
22) A formulation for treating a tumor or cancerous growth localized to a tissue or organ in a subject comprising a therapeutically effective amount of a tumor vaccine which generates an immune response against the tumor or cancerous growth;
25) A kit for generating a systemic immune response against an organ or tissue-specific disease or condition in a subject comprising:
26) A kit for treating a tumor or cancerous growth localized to a tissue or organ in a subject comprising:
Dependencies are inferred from the claim text.