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US 2006/0051359 A1Published application
Recombinant immunotoxin and use in treating tumors
OwnerIra Pastan, Masanori Onda +1inventors
InventorsIra Pastan, Masanori Onda, Nai-Kong Cheung
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Abstract
Immunotoxins are disclosed that include a toxin, a variable region of a heavy chain of a monoclonal antibody that binds the antigen specifically bound by monoclonal antibody 8H9, and a variable region of a light chain of the monoclonal antibody that binds the antigen specifically bound by monoclonal antibody 8H9 and effector molecule. These immunotoxins include scFv and dsFv of monoclonal antibody 8H9. The immunotoxins are of use for the treatment of tumors.
Claims28
An isolated Fv protein, comprising:
- a) a variable region of a heavy chain of a monoclonal antibody that binds the antigen specifically bound by monoclonal antibody 8H9 and a variable region of a light chain of the monoclonal antibody that binds the antigen specifically bound by monoclonal antibody 8H9 wherein the variable region of a heavy chain of a monoclonal antibody that binds the antigen specifically bound by monoclonal antibody 8H9 and the variable region of a light chain of the monoclonal antibody that binds the antigen specifically bound by monoclonal antibody 8H9 are covalently linked by disulfide bonds;
- and
- b) an effector molecule comprising a toxin;
- wherein the Fv protein specifically binds the epitope bound by monoclonal antibody 8H9.
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Dependencies are inferred from the claim text.