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US 2006/0051346 A1Published application
Humanized anti-CD4 antibody with immunosuppressive properties
AssigneeBiotest AG
InventorJohn Wijdenes
Life of this patent
Estimating the term…
Abstract
A humanized antibody derived from mouse monoclonal anti-CD4 antibody B-F5 is able to activate CD25+CD4+ regulatory T cells and is useful for preparing immunosuppressive compositions.
Claims9
1) A humanized hB-F5 antibody derived from mouse monoclonal anti-CD4 antibody B-F5, wherein said hB-F5 antibody comprises V domains selected from the group consisting of:
- a) H chain V domain comprising the sequence,
- (SEQ ID NO:
- 1)
- EEQLVESGGGLVKPGGSLRLSCAASGFSFSDCRMYWLRQAPGKGLEWIGV
- ISVKSENYGANYAESVRGRFTJSRDDSKNTVYLQMNSLKTEDTAVYYCSA
- SYYRYDVGAWFAYWGQGTLVTVSS
- b) L chain V domain comprising the sequence:
- (SEQ ID NO:
- 2)
- DIVMTQSPDSLAVSLGERATFNCRASKSVSTSGYSYIYWYQQKPGQPPKL
- LIYLASILESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQHSRELPW
- TFGQGTKVEIK,
- and
- c) combinations thereof,
- wherein said hB-F5 antibody is able to activate a subset of T CD4+ cells comprising CD4+ CD25+ cells.
12 more elements
3) A polynucleotide selected from the group consisting of:
- a) a polynucleotide comprising a sequence encoding the H chain V domain of SEQ ID NO:
- 1;
- and
- b) a polynucleotide comprising a sequence encoding the L chain V domain of SEQ ID NO:
- 2.
2 more elements
Dependencies are inferred from the claim text.