Method for treating multiple sclerosis
AssigneeGenentech, Inc.
InventorPaul Frohna
Life of this patent
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Abstract
Methods for treating multiple sclerosis (MS) with a CD20 antibody using special dosing regimens and protocols are described. Articles of manufacture for use in such methods are also described.
Claims38
A method of treating multiple sclerosis in a subject comprising administering an effective amount of a CD20 antibody to the subject to provide an initial antibody exposure of about 0.5 to 4 grams followed by a second antibody exposure of about 0.5 to 4 grams, the second exposure not being provided until from about 16 to 60 weeks from the initial exposure, and each of the antibody exposures is provided to the subject as one or two doses of antibody.
An article of manufacture comprising:
- (a) a container comprising a CD20 antibody;
- and
- (b) a package insert with instructions for treating multiple sclerosis in a subject, wherein the instructions indicate that an amount of the antibody is administered to the subject that is effective to provide an initial antibody exposure of about 0.5 to 4 grams followed by a second antibody exposure of about 0.5 to 4 grams, the second exposure not being administered until from about 16 to 60 weeks from the initial exposure, and each of the antibody exposures is provided to the subject as one or two doses of antibody.
Dependencies are inferred from the claim text.