Substituted hydantoins

A compound selected from the group consisting of

• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-[(R)-4-(4-methoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyramide;
• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-[(R)-4-(4-hydroxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyramide;
• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-{(R)-4-[4-(2-hydroxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-butyramide;
• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-{(R)-4-[4-(2-methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-butyramide;
• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-((R)-4-{4-[2-(2-methoxy-ethoxy)-ethoxy]-phenyl}-2,5-dioxo-imidazolidin-1-yl)-3-phenyl-butyramide;
• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-{(R)-4-[4-(2-ethoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-butyramide;
• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-{(R)-4-[4-(2-dimethylamino-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-butyramide;
• compound with trifluoro-acetic acid
• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-{(R)-4-[4-(2-diethylamino-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-butyramide;
• compound with trifluoro-acetic acid
• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-[(R)-4-(4-ethoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyramide;
• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-{(S)-4-[4-(2-dimethylamino-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-butyramide;
• compound with trifluoro-acetic acid
• (4-{1-[(1S,2S)-1-(4-Acetyl-thiazol-2-ylcarbamoyl)-2-phenyl-propyl]-2,5-dioxo-imidazolidin-4-yl}-phenyl)-phosphonic acid diethyl ester;
• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-[4-(4-dimethylamino-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyramide;
• (2S,3S)-2-[(R)-4-(4-Methoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-pentanoic acid (4-acetyl-thiazol-2-yl)-amide;
• (2S,3S)-2-[(R)-4-(4-Methoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-[(R)-4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-[(R)-4-(4-Ethoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-[(R)-4-(4-Hydroxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-{(R)-4-[4-(2-Methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-{(S)-4-[4-(2-Methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-{(R)-4-[4-(2-Hydroxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-((R)-4-{4-[2-(2-Methoxy-ethoxy)-ethoxy]-phenyl}-2,5-dioxo-imidazolidin-1-yl)-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide and
• (2S,3S)-2-{(R)-4-[4-(2-Ethoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide.

A compound selected from the group consisting of

• (2S,3S)-2-{(R)-4-[4-(2-Ethoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-{(R)-4-[4-(2-Dimethylamino-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• compound with trifluoro-acetic acid
• (4-{(R)-2,5-Dioxo-1-[(1S,2S)-2-phenyl-1-(4-propionyl-thiazol-2-ylcarbamoyl)-propyl]-imidazolidin-4-yl}-phenoxymethyl)-phosphonic acid dimethyl ester;
• (2S,3S)-N-(4-Isobutyryl-thiazol-2-yl)-2-{4-[4-(2-methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-butyramide;
• (2S,3S)-N-(4-Isobutyryl-thiazol-2-yl)-2-[(R)-4-(4-methoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyramide;
• (2S,3S)-2-{(S)-4-[4-(2-Dimethylamino-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-enyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• compound with trifluoro-acetic acid;
• (2S,3S)-2-{2,5-Dioxo-4-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-imidazolidin-1-yl}-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-{4-[4-(2-Morpholin-4-yl-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-3-(3-Fluoro-phenyl)-2-{(R)-4-[4-(2-methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-[(R)-4-(4-Methoxy-3-methyl-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-{(S)-4-[4-(2-Hydroxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-((R)-2,5-Dioxo-4-phenyl-imidazolidin-1-yl)-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-[4-(4-Dimethylamino-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-[4-(4-Morpholin-4-yl-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-{4-[4-(4-Hydroxy-piperidin-1-yl)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-(4-{4-[(2-Methoxy-ethyl)-methyl-amino]-phenyl}-2,5-dioxo-imidazolidin-1-yl)-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,2S)-N-(4-Cyclopropanecarbonyl-thiazol-2-yl)-2-{(R)-4-[4-(2-methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-butyramide;
• (2S,3S)-2-{4-[4-(2-Methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-methyl-pentanoic acid (4-propionyl-thiazol-2-yl)-amide;
• (2S,3R)-3-Benzyloxy-2-{(R)-4-[4-(2-methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-N-[4-(2-Methoxy-acetyl)-thiazol-2-yl]-2-[(R)-4-(4-methoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyramide;
• 2-{(2S,3S)-2-[(R)-4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyrylamino}-thiazole-4-carboxylic acid methyl ester and
• 2-[(2S,3S)-2-((R)-2,5-Dioxo-4-phenyl-imidazolidin-1-yl)-3-phenyl-butyrylamino]-thiazole-4-carboxylic acid methyl ester.

A compound selected from the group consisting of

• 2-{(2S,3S)-2-[(R)-4-(4-Methoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyrylamino}-thiazole-4-carboxylic acid methyl ester;
• 2-{(2S,3S)-2-[(R)-4-(4-Hydroxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyrylamino}-thiazole-4-carboxylic acid methyl ester;
• 2-((2S,3S)-2-{(R)-4-[4-(2-Methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-butyrylamino)-thiazole-4-carboxylic acid methyl ester;
• 2-((2S,3S)-2-{(R)-4-[4-(2-Hydroxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-butyrylamino)-thiazole-4-carboxylic acid methyl ester;
• 2-{(2S,3S)-2-[(R)-4-(4-Isopropoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyrylamino}-thiazole-4-carboxylic acid methyl ester;
• 2-{(2S,3S)-2-[(R)-4-(4-Methoxy-3-methyl-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyrylamino}-thiazole-4-carboxylic acid methyl ester;
• 2-((2S,3S)-2-{(R)-4-[4-(Dimethoxy-phosphorylmethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-butyrylamino)-thiazole-4-carboxylic acid methyl ester;
• 2-{(2S,3S)-3-(2-Methoxy-phenyl)-2-[4-(4-methoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-butyrylamino}-thiazole-4-carboxylic acid methyl ester;
• 2-((2S,3S)-3-(4-Fluoro-phenyl)-2-{(R)-4-[4-(2-methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-butyrylamino)-thiazole-4-carboxylic acid methyl ester;
• 2-{(2S,3S)-2-[(R)-4-(4-Methoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-methyl-pentanoylamino}-thiazole-4-carboxylic acid methyl ester;
• 2-[(2S,3S)-2-((R)-2,5-Dioxo-4-phenyl-imidazolidin-1-yl)-3-methyl-pentanoylamino]-thiazole-4-carboxylic acid methyl ester;
• 2-((2S,3S)-2-{(R)-4-[4-(2-Methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-methyl-pentanoylamino)-thiazole-4-carboxylic acid methyl ester;
• 2-{(2S,3R)-3-Hydroxy-2-[(R)-4-(4-methoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-butyrylamino}-thiazole-4-carboxylic acid methyl ester;
• 2-((2S,3R)-3-Hydroxy-2-{(R)-4-[4-(2-methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-butyrylamino)-thiazole-4-carboxylic acid methyl ester;
• 2-((2S,3R)-3-tert-Butoxy-2-{(R)-4-[4-(2-methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-butyrylamino)-thiazole-4-carboxylic acid methyl ester;
• 2-{(2S,3R)-3-Methoxy-2-[(R)-4-(4-methoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-butyrylamino}-thiazole-4-carboxylic acid methyl ester;
• 2-((2S,3R)-3-Methoxy-2-{(R)-4-[4-(2-methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-butyrylamino)-thiazole-4-carboxylic acid methyl ester;
• 2-((2S,3R)-3-Benzyloxy-2-{(R)-4-[4-(2-methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-butyrylamino)-thiazole-4-carboxylic acid methyl ester;
• 2-((2S,3R)-3-(4-Chloro-benzyloxy)-2-{(R)-4-[4-(2-methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-butyrylamino)-thiazole-4-carboxylic acid methyl ester
• 2-{(2S,3R)-2-[(R)-4-(4-Methoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-methyl-pentanoylamino}-thiazole-4-carboxylic acid methyl ester
• 2-((2S,3R)-2-{(R)-4-[4-(2-Methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-methyl-pentanoylamino)-thiazole-4-carboxylic acid methyl ester;
• 2-((2S,3R)-2-{(R)-4-[4-(2-Methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-methyl-pentanoylamino)-thiazole-4-carboxylic acid methyl ester;
• 2-{(2S,3S)-2-[4-(4-Methanesulfonyl-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyrylamino}-thiazole-4-carboxylic acid methyl ester and
• 2-{(S)-2-[(R)-4-(4-Methoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-methyl-3-phenyl-butyrylamino}-thiazole-4-carboxylic acid methyl ester.

A compound selected from the group consisting of

• 2-{(2S,3R)-2-[(R)-4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyrylamino}-thiazole-4-carboxylic acid methyl ester;
• 2-{(2S,3S)-2-[(R)-4-(4-Acetylamino-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyrylamino}-thiazole-4-carboxylic acid methyl ester;
• N-[4-(1-Hydroxy-1-methyl-ethyl)-thiazol-2-yl]-2-[(R)-4-(4-methoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyramide;
• (2S,3S)-2-[(R)-4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-2,5-dioxo-imidazolidin-1-yl]-N-[4-(1-hydroxy-propyl)-thiazol-2-yl]-3-phenyl-butyramide;
• (2S,3S)-N-[4-(1-Hydroxy-ethyl)-thiazol-2-yl]-2-[(R)-4-(4-methoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyramide;
• 2-{(2S,3S)-2-[(R)-4-(4-Methoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyrylamino}-thiazole-4-carboxylic acid dimethylamide;
• (2S,3S)-N-(4-Ethylsulfanyl-thiazol-2-yl)-2-{(R)-4-[4-(2-methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-butyramide;
• (2S,3S)-N-(4-Ethanesulfinyl-thiazol-2-yl)-2-{(R)-4-[4-(2-methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-butyramide;
• (2S,3S)-N-(4-Ethanesulfonyl-thiazol-2-yl)-2-{(R)-4-[4-(2-methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-butyramide;
• (2S,3S)-N-[4-(2-Hydroxy-acetyl)-thiazol-2-yl]-2-{(R)-4-[4-(2-methoxy-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-butyramide;
• (4-{(R)-1-[(1S,2S)-1-(4-Acetyl-thiazol-2-ylcarbamoyl)-2-phenyl-propyl]-2,5-dioxo-imidazolidin-4-yl}-phenoxy)-acetic acid methyl ester;
• (4-{(R)-2,5-Dioxo-1-[(1S,2S)-2-phenyl-1-(4-propionyl-thiazol-2-ylcarbamoyl)-propyl]-imidazolidin-4-yl}-phenoxy)-acetic acid methyl ester;
• (4-{2,5-Dioxo-1-[(1S,2S)-2-phenyl-1-(4-propionyl-thiazol-2-ylcarbamoyl)-propyl]-imidazolidin-4-yl}-phenoxy)-acetic acid;
• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-[(R)-4-(4-dimethylcarbamoylmethoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyramide;
• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-[(R)-4-(4-methylcarbamoylmethoxy-phenyl)-2,5 dioxo-imidazolidin-1-yl]-3-phenyl-butyramide;
• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-[(R)-4-(4-carbamoylmethoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyramide and
• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-((R)-4-{4-[(2-methoxy-ethylcarbamoyl)-methoxy]-phenyl}-2,5-dioxo-imidazolidin-1-yl)-3-phenyl-butyramide.

A compound selected from the group consisting of

• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-((R)-4-{4-[(2-methoxy-ethylcarbamoyl)-methoxy]-phenyl}-2,5-dioxo-imidazolidin-1-yl)-3-phenyl-butyramide;
• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-((R)-4-{4-[(2-methoxy-ethylcarbamoyl)-methoxy]-phenyl}-2,5-dioxo-imidazolidin-1-yl)-3-phenyl-butyramide;
• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-{(R)-4-[4-(2-morpholin-4-yl-2-oxo-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-butyramide;
• (2S,3S)-N-(4-Acetyl-thiazol-2-yl)-2-{(R)-2,5-dioxo-4-[4-(2-oxo-2-pyrrolidin-1-yl-ethoxy)-phenyl]-imidazolidin-1-yl}-3-phenyl-butyramide;
• (2S,3S)-2-[(R)-4-(4-Dimethylcarbamoylmethoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-[(R)-4-(4-Methylcarbamoylmethoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-((R)-4-{4-[(2-Methoxy-ethylcarbamoyl)-methoxy]-phenyl}-2,5-dioxo-imidazolidin-1-yl)-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-{(R)-4-[4-(2-Morpholin-4-yl-2-oxo-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-{(R)-2,5-Dioxo-4-[4-(2-oxo-2-pyrrolidin-1-yl-ethoxy)-phenyl]-imidazolidin-1-yl}-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide;
• (2S,3S)-2-{(R)-4-[4-(2-Azetidin-1-yl-2-oxo-ethoxy)-phenyl]-2,5-dioxo-imidazolidin-1-yl}-3-phenyl-N-(4-propionyl-thiazol-2-yl)-butyramide and
• (2S,3S)-N-(4-Cyclopropanecarbonyl-thiazol-2-yl)-2-[(R)-4-(4-methylcarbamoylmethoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyramide.

A method of treating a disease mediated by MEK1/2 inhibition which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of the formula

• wherein:
• R1 is selected from the group consisting of a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl group
• R2 is hydrogen
• R3 is selected from a mono- or di-alkyl group;
• R4 is selected from the group consisting of a substituted or unsubstituted aryl, hydroxyl, alkoxy, substituted alkoxy or a substituted or unsubstituted heteroaryl or alkyl group;
• R5 is selected from the group consisting of COOR, COR, CON(R7)2 or CHOHR wherein R is alkyl
• or alkyl substituted by an alkoxy group;
• and
• R6 and R7 are selected from hydrogen or an alkyl group or the pharmaceutically acceptable salts or esters or prodrugs thereof.

A pharmaceutical composition comprising a compound of the formula

• wherein:
• R1 is selected from the group consisting of a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl group
• R2 is hydrogen
• R3 is selected from a mono- or di-alkyl group;
• R4 is selected from the group consisting of a substituted or unsubstituted aryl, hydroxyl, alkoxy, substituted alkoxy or a substituted or unsubstituted heteroaryl or alkyl group;
• R5 is selected from the group consisting of COOR, COR, CON(R7)2 or CHOHR wherein R is alkyl
• or alkyl substituted by an alkoxy group;
• and
• R6 and R7 are selected from hydrogen or an alkyl group
• or the pharmaceutically acceptable salts or esters or prodrugs thereof and a pharmaceutically acceptable carrier.