Method for producing salts of tolperisone
AssigneeSanochemia Pharmazeutika AG
InventorsLaszlo Czollner, Beate Kalz, Jan Rothenburger, Stefan Welzig
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Abstract
The invention relates to a method for producing an addition salt of 2,4′-dimethyl-3-piperidino-propiophenone (tolperisone) with a pharmaceutically acceptable acid, of formula (I). According to the invention, 4-methylpropiophenone is reacted with piperidine hydrochloride and 1,2-dioxolane in the presence of an acid serving as a catalyst, and the tolperisone obtained in the form of an acid addition salt is separated by filtering after the reaction mixture has cooled down.
Claims7
A method for manufacturing pharmaceutically acceptable acid addition salts of 2,4′-dimethyl-3-piperidinopropiophenone (tolperisone), of formula (A)
- said acid addition salts having a formula (B)
- comprising reacting 4-methylpropiophenone of the formula
- with piperidine hydrochloride of the formula
- and 1,2-dioxolane of the formula
- in the presence of a catalytic amount of an acid, wherein tolperisone is separated as an acid addition salt in accordance with the general formula (B) after cooling the reaction mixture by addition of ethyl acetate and tert-butylmethylether to cause precipitation.
2-5. (canceled)
Dependencies are inferred from the claim text.