Erythropoietin production accelerator

A preventive or therapeutic agent for anemia, comprising as an active ingredient, a cyclic amine compound represented by the following formula (1):

• wherein,
• R1, R2 and R3 each independently represent a hydrogen atom, a halogen atom, or hydroxy, alkyl, halogen-substituted alkyl, alkoxy, alkylthio, carboxyl, alkoxycarbonyl or alkanoyl group;
• W1 and W2 each independently represent N or CH;
• X represents O, NR4, CONR4 or NR4CO;
• R4 each represents a hydrogen atom, or an alkyl, alkenyl, alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroaralkyl group;
• and
• l, m and n each represents a number of 0 or 1, or a salt thereof or a solvate thereof.

A preventive or therapeutic agent for chronic anemia, renal anemia, anaplastic anemia or pure red cell aplasia, comprising as an active ingredient, a cyclic amine compound represented by the following formula (1):

• wherein,
• R1, R2 and R3 each independently represent a hydrogen atom, a halogen atom, or hydroxy, alkyl, halogen-substituted alkyl, alkoxy, alkylthio, carboxyl, alkoxycarbonyl or alkanoyl group;
• W1 and W2 each independently represent N or CH;
• X represents O, NR4, CONR4 or NR4CO;
• R4 each represents a hydrogen atom, or an alkyl, alkenyl, alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroaralkyl group;
• and
• l, m and n each represents a number of 0 or 1, or a salt thereof or a solvate thereof.

Use of a cyclic amine compound represented by the following formula (1):

• wherein,
• R1, R2 and R3 each independently represent a hydrogen atom, a halogen atom, or hydroxy, alkyl, halogen-substituted alkyl, alkoxy, alkylthio, carboxyl, alkoxycarbonyl or alkanoyl group;
• W1 and W2 each independently represent N or CH;
• X represents O, NR4, CONR4 or NR4CO;
• R4 each represents a hydrogen atom, or an alkyl, alkenyl, alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroaralkyl group;
• and
• l, m and n each represents a number of 0 or 1, or a salt thereof or a solvate thereof for the manufacture of a preventive or therapeutic agent for pathological conditions caused by reduced production of erythropoietin.

Use of a cyclic amine compound represented by the following formula (1):

• wherein,
• R1, R2 and R3 each independently represent a hydrogen atom, a halogen atom, or hydroxy, alkyl, halogen-substituted alkyl, alkoxy, alkylthio, carboxyl, alkoxycarbonyl or alkanoyl group;
• W1 and W2 each independently represent N or CH;
• X represents O, NR4, CONR4 or NR4CO;
• R4 each represents a hydrogen atom, or an alkyl, alkenyl, alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroaralkyl group;
• and
• l, m and n each represents a number of 0 or 1, or a salt thereof or a solvate thereof for the manufacture of a preventive or therapeutic agent for anemia.

Use of a cyclic amine compound represented by the following formula (1):

• wherein,
• R1, R2 and R3 each independently represent a hydrogen atom, a halogen atom, or hydroxy, alkyl, halogen-substituted alkyl, alkoxy, alkylthio, carboxyl, alkoxycarbonyl or alkanoyl group;
• W1 and W2 each independently represent N or CH;
• X represents O, NR4, CONR4 or NR4CO;
• R4 each represents a hydrogen atom, or an alkyl, alkenyl, alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroaralkyl group;
• and
• l, m and n each represents a number of 0 or 1, or a salt thereof or a solvate thereof for the manufacture of a preventive or therapeutic agent for chronic anemia, renal anemia, aplastic anemia, or pure red cell aplasia.

A method of treating pathological conditions caused by reduced production of erythropoietin, comprising administering an effective amount of a cyclic amine compound represented by the following formula (1):

• wherein,
• R1, R2 and R3 each independently represent a hydrogen atom, a halogen atom, or hydroxy, alkyl, halogen-substituted alkyl, alkoxy, alkylthio, carboxyl, alkoxycarbonyl or alkanoyl group;
• W1 and W2 each independently represent N or CH;
• X represents O, NR4, CONR4 or NR4CO;
• R4 each represents a hydrogen atom, or an alkyl, alkenyl, alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroaralkyl group;
• and
• l, m and n each represents a number of 0 or 1, or a salt thereof or a solvate thereof.

A method of treating anemia, comprising administering an effective amount of a cyclic amine compound represented by the following formula (1):

• wherein,
• R1, R2 and R3 each independently represent a hydrogen atom, a halogen atom, or hydroxy, alkyl, halogen-substituted alkyl, alkoxy, alkylthio, carboxyl, alkoxycarbonyl or alkanoyl group;
• W1 and W2 each independently represent N or CH;
• X represents O, NR4, CONR4 or NR4CO;
• R4 each represents a hydrogen atom, or an alkyl, alkenyl, alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroaralkyl group;
• and
• l, m and n each represents a number of 0 or 1, or a salt thereof or a solvate thereof.

A method of treating chronic anemia, renal anemia, aplastic anemia, or pure red cell aplasia, comprising administering an effective amount of a cyclic amine compound represented by the following formula (1):

• wherein,
• R1, R2 and R3 each independently represent a hydrogen atom, a halogen atom, or hydroxy, alkyl, halogen-substituted alkyl, alkoxy, alkylthio, carboxyl, alkoxycarbonyl or alkanoyl group;
• W1 and W2 each independently represent N or CH;
• X represents O, NR4, CONR4 or NR4CO;
• R4 each represents a hydrogen atom, or an alkyl, alkenyl, alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroaralkyl group;
• and
• l, m and n each represents a number of 0 or 1, or a salt thereof or a solvate thereof.