Methods of use related to xerostomia
OwnerMartin Stogniew, David Alberts +1inventors
InventorsMartin Stogniew, David Alberts, Edward Kaplan
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Abstract
The present invention relates to new uses of thermally stable, crystalline S-2-(3-aminopropylamino)ethyl dihydrogen phosphorothioate, (amifostine) and other aminothiol compounds to treat and reverse toxicities caused by radiation treatment. In particular, the invention provides a method for treating or preventing xerostomia associated with the administration of radiation treatment of head and neck cancer.
Claims39
A method for treating xerostomia associated with radiation therapy for head and neck cancer in a human, which comprises administering to said human a therapeutically effective amount of a dosage form comprising a thermally stable, sterile, crystalline compound of the formula:
- R1NH(CH2)nNH(CH2)mSR2
- or a pharmaceutically acceptable addition salt or hydrate thereof, wherein
- R1 is hydrogen, C5-C7 aryl, C2-C7 acyl, or C1-C7 alkyl;
- R2 is hydrogen, PO3H2 or R3 wherein R3 is R1NH(CH2)nNH(CH2)mS—;
- n is an integer from 1 to 10;
- and
- m is an integer from 1 to 10.
A method for treating xerostomia associated with radiation therapy for head and neck cancer in a human, which comprises administering to said human a therapeutically effective amount of a dosage form comprising a thermally stable, sterile, crystalline amifostine.
Dependencies are inferred from the claim text.