Method of searching for and generating polymrophs of a substance
OwnerPoongunran Muthukumaran, Lalit Chordiainventors
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Abstract
The present invention provides a method and apparatus for producing polymorphs of a desired substance providing a plurality of enclosed spaces. The temperature and pressure of the enclosed spaces can be controlled. Various crystal identification means can be used to identify the polymorphic form of the solidified substance.
Claims39
A method and apparatus for producing polymorphs of a desired substance comprising the steps of:
- a. Providing a plurality of enclosed spaces
- b. Transferring the dispersions of the desired substance in at least one solvent into different enclosed spaces;
- and
- c. Applying a compressed antisolvent to the enclosed spaces to solidify the desired substance
The method and apparatus as in any one of the above claims wherein the transfer of dispersion and application of antisolvent are carried out simultaneously.
The method and apparatus as in 35 wherein the small dispensing means can handle microliter quantities.
The method and apparatus as in 35 wherein the small dispensing means can handle nanoliter quantities.
The method and apparatus as in 35 wherein the small dispensing means can handle picoliter quantities.
The method and apparatus as in 35 wherein the small dispensing means can handle femptoliter quantities.
Dependencies are inferred from the claim text.