Regulation of novel human asparagine-hydroxylases

An isolated polynucleotide being selected from the group consisting of:

• a) a polynucleotide encoding an asparagine-hydroxylase polypeptide comprising an amino acid sequence selected from the group constisting of
• i) amino acid sequences which are at least about 36% identical to the amino acid sequence shown in SEQ ID NO:
• 2;
• and
• ii) the amino acid sequence shown in SEQ ID NO:
• 2;
• iii) amino acid sequences which are at least about 38% identical to the amino acid sequence shown in SEQ ID NO:
• 4;
• and
• iv) the amino acid sequence shown in SEQ ID NO:
• 4;
• v) amino acid sequences which are at least about 28% identical to the amino acid sequence shown in SEQ ID NO:
• 6;
• and
• vi) the amino acid sequence shown in SEQ ID NO:
• 6.
• b) a polynucleotide comprising the sequence of SEQ ID NO:
• 1, 3 or 5;
• c) a polynucleotide which hybridizes under stringent conditions to a polynucleotide specified in (a) and (b) and encodes an asparagine-hydroxylase;
• d) a polynucleotide the nucleic acid sequence of which deviates from the nucleic acid sequences specified in (a) to (c) due to the degeneration of the genetic code and encodes an asparagine-hydroxylase;
• and
• e) a polynucleotide, which represents a fragment derivative or allelic variation of a nucleic acid sequence specified in (a) to (d) and encodes an asparagine-hydroxylase.