Multiparticulate formulations of lithium salts for oral administration suitable for once-a-day administration
AssigneeVal Pharma S.A.
InventorsRoberto Valducci, Tiziano Alighieri, Serozh Avanessian
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Abstract
This invention refers to: multiparticulate formulations of Lithium salts for oral administration constituted by either modified release granules or mixtures of modified and conventional release granules, suitable for once-a-day administration also at high strengths of Lithium salts, and to the preparation process of said formulations.
Claims14
1) A multiparticulate formulation comprising a plurality of microgranules or micro-tablets having dimensions ranging from 200 to 2000 micrometers and each microgranule or microtablet containing granulated Lithium salts and a binder, said plurality of microgranules or micro-tablets being coated microgranules or microtablets having a modified release, said formulation having a Lithium salt content of at least 500 mg/g and said mixture having sufficient modified release coated microgranules or microtablets to have an in vitro dissolution profile suitable for once-a-day administration.
10) A multiparticulate formulation comprising a plurality of microgranules or micro-tablets having dimensions ranging from 200 to 2000 micrometers and each microgranule or microtablet containing granulated Lithium salts and a binder, said plurality of microgranules or micro-tablets being coated microgranules or microtablets having a modified release, said formulation having a Lithium salt content of at least 500 mg/g and said mixture having sufficient modified release coated microgranules or microtablets to have an in vitro dissolution profile suitable for once-a-day administration, said binder being polyvinlypyrolidone, said coating being ethylcellulose, said lithium salt being lithium carbonate, said formulation containing talc.
Dependencies are inferred from the claim text.