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OwnerAlberto Gorrochategui Barrueta, Josu Simon Elizundia +1inventors
InventorsAlberto Gorrochategui Barrueta, Josu Simon Elizundia, Emilio Barbera-Guillem
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A biological tissue regenerative agent and method for preparing the same. The agent comprises the compounds that are usually found sequestered within platelets, along with platelet cytosolic components, and serum. The agent is prepared by preparing two quanta of blood. The first is clotted, the cells discarded and the serum retained. The second quantum undergoes concentration and lysis of the platelets therein, followed by recombination of the lysed platelets and platelet internal products with serum to form the agent. In a preferred embodiment, lysis of platelets is accomplished by providing an effective amount of calcium. The avoidance of a platelet release reaction and the presence of alpha-2 macroglobulin in the serum suppresses active TGF-β in the agent. The agent may be further purified and may be frozen or freeze dried for storage.
A biological tissue regenerative agent for facilitating tissue growth comprising the materials released by platelet lysis, further comprising compounds normally contained in platelet a-granules, dense bodies, and cytosol;
A process for producing a biological tissue regenerative agent comprising the steps of:
A method for treating live animal tissue comprising applying to the tissue an effective amount of a biological tissue regenerative agent comprising a plurality of materials released by platelet lysis, and a quantum of serum, facilitating tissue growth.
Dependencies are inferred from the claim text.