Stinging cells expressing an exogenous polycleotide encoding a therpeutic, diagnostics or a cosmetic agent and methods compositions and devices utilizing such stinging cells or capsules derive therefrom for delivering the therapeutic, diagnostic or cosmetic agent into a tissue
AssigneeNanoCyte Inc.
InventorsTamar Lotan, Shimon Eckhouse, Esther Shaoul
Life of this patent
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Abstract
A stinging cell comprising an exogenous polynucleotide capable of expressing a therapeutic, cosmetic or diagnostic agent in the stinging cell is provided.
Claims74
A stinging cell or a stinging cell progenitor comprising an exogenous polynucleotide capable of expressing a therapeutic, cosmetic or diagnostic agent in the stinging cell.
A pharmaceutical composition comprising, as an active ingredient, a stinging cell expressing an exogenous polynucleotide encoding a therapeutic, cosmetic or diagnostic agent and a pharmaceutically acceptable carrier.
A delivery device comprising:
- (a) at least one stinging cell expressing an exogenous polynucleotide encoding a therapeutic, cosmetic or diagnostic agent;
- and
- (b) a support being for:
- (i) supporting said at least one stinging cell;
- and
- (ii) applying said at least one stinging cell to an outer surface of a tissue.
A method of delivering a therapeutic or a cosmetic agent into a tissue, the method comprising the steps of:
- (a) transforming at least one stinging cell or stinging cell progenitor with a polynucleotide encoding a therapeutic, cosmetic or diagnostic agent to thereby generate at least one stinging cell expressing said therapeutic, cosmetic or diagnostic agent;
- (b) applying said at least one stinging cell expressing said therapeutic,
- cosmetic or diagnostic agent to an outer surface of the tissue;
- and
- (c) triggering a discharge of said at least one stinging cell to thereby deliver said therapeutic, cosmetic or diagnostic agent into the tissue.
A method of delivering a polypeptide into a tissue, the method comprising the steps of:
- (a) transforming at least one stinging cell or stinging cell progenitor with a polynucleotide designed for expressing a polypeptide being capable of self-targeting into a stinging capsule of said at least one stinging cell;
- (b) isolating said stinging capsule from at least one stinging cell;
- (c) applying said at least one stinging capsule to an outer surface of the tissue;
- and
- (d) triggering a discharge of said at least one stinging capsule to deliver said polypeptide into the tissue.
An expression construct or construct system comprising a first polynucleotide sequence encoding a therapeutic, cosmetic or diagnostic agent and a second polynucleotide sequence encoding a molecule capable of at least partially downregulating activity or generation of a toxin naturally produced by a stinging cell.
Dependencies are inferred from the claim text.