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US 2006/0039863 A1Published application
Use of cyanine dyes for the diagnosis of disease associated with angiogenesis
OwnerMichael Schirner, Kai Licha +2inventors
InventorsMichael Schirner, Kai Licha, Peter Hauff, Christin Perlitz
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Abstract
This invention relates to the use of conjugates of cyanine dyes with an angiogenesis specific binding component preferably with an EB-D fibronectin specific binding component for the diagnosis of micrometastasis and small proliferative lesions, in particular primary tumors, precancerosis, dysplasia, metaplasia, inflammatory lesions, e.g. psoriasis, psoriatic arthritis and/or rheumatoid arthritis, endometriotic lesions, and ocular diseases associated with angiogenesis.
Claims29
Use of a conjugate of the general formula (I):
- B-(D)n (I),
- wherein
- B stands for an angiogenesis specific binding component,
- D stands for a cyanine dye, and
- n is 1 to 5
- for the production of a diagnostic for the diagnosis of micrometastasis or small proliferative lesions.
3 more elements
Dependencies are inferred from the claim text.