LPAAT-beta inhibitors and uses thereof
AssigneeCell Therapeutics, Inc.
InventorsLynn Bonham, J. Klein, Robert Finney, David Hollenback, Scott Shaffer, Norina Tang, Thayer White, David Leung, Baoqing Gong, John Tulinsky
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Abstract
The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase β (LPMT-β) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-β activity.
Claims7
A compound of the Formula:
- wherein,
- R1 is halo, hydroxy, alkylmercapto, mercapto, alkoxy, aryloxy or —NRR wherein each R group is independently selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, aryl, or the R groups are joined together to form a heterocyclic ring with the N;
- R2, R3, R4 and R5, each of which may be same or different, are hydrogen, alkyl, substituted alkyl, alkenyl, alkynyl, aryl or aryl substituted with 1 to 3 substituents selected from hydroxy, alkoxy and halogen;
- or
- R2 and R3 or R4 and R5, together with the nitrogen to which they are attached, form a piperidine, piperazine, or a morpholine ring;
- or
- pharmaceutically acceptable salt thereof.
A compound selected from N-butyl-6-chloro-N′-(4-chlorophenyl)-[1,3,5]triazine-2,4-diamine, N-tert-butyl-6-chloro-N′-phenyl-[1,3,5]triazine-2,4-diamine, (4-chloro-6-morpholin-4-yl-[1,3,5]triazin-2-yl)-naphthalen-1-yl-amine, 6-chloro-N-cyclo-hexyl-N′-isopropyl-[1,3,5]triazine-2,4-diamine, 2-(4-chloro-6-phenylamino-[1,3,5]triazin-2-ylamino)-2-methyl-propan-1-ol, 6-chloro-N-isopropyl-N′-phenyl-[1,3,5]triazine-2,4-diamine, 6-chloro-N-(4-chloro-phenyl)-N′-cyclohexyl-[1,3,5]triazine-2,4-diamine, N-allyl-6-chloro-N′-cyclohexyl-[1,3,5]triazine-2,4-diamine, 2-(4-chloro-6-phenylamino-[1,3,5]triazin-2-ylamino)-ethanol, N-tert-butyl-6-chloro-N′-cyclopentyl-[1,3,5]triazine-2,4-diamine, 6-chloro-N-(4-methoxyphenyl)-N′-phenyl-[1,3,5]triazine-2,4-diamine, N-benzo[1,3]dioxol-5-yl-6-chloro-N′-(4-chlorophenyl)-[1,3,5]triazine-2,4-diamine, 6-chloro-N-(2,3-dihydrobenzo[1,4]dioxin-6-yl)-N′-phenyl-[1,3,5]triazine-2,4-diamine, N-benzo[1,3]dioxol-5-yl-6-chloro-N′-phenyl-[1,3,5]triazine-2,4-diamine, 6-chloro-N-indan-5-yl-N′-phenyl-[1,3,5]triazine-2,4-diamine, 6-chloro-N-(4-chloro-phenyl)-N′-propyl-[1,3,5]triazine-2,4-diamine, N-(4-chloro-phenyl)-6-methoxy-N′-propyl-[1,3,5]triazine-2,4-diamine and N-(4-chloro-phenyl)-6-methylmercapto-N′-phenyl-[1,3,5]triazine-2,4-diamine.
Dependencies are inferred from the claim text.