Method for producing matrices of addressed ligands on a carrier
AssigneeCommissariat a l'Energie Atomique
InventorsThierry Livache, Frederic Lesbre
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Abstract
The invention concerns a method for fabricating matrices of addressed ligands on a carrier. According to this method, an element is used such as a reservoir (1) filled with ligand and containing an electrode (3) to deposit and electrochemically fix the ligand to the conductive carrier (7). The ligand may be an oligonucleotide or a peptide, and fixing may be obtained by electropolymerisation of this oligonucleotide or peptide carrying a pyrrole group at 5′ with pyrrole.
Claims5
1-15. (canceled)
Device for producing a matrix of ligands on a conductive carrier or on conductive zones of a carrier, comprising:
- at least one ligand dispensing means (1) provided with a conductive part (3),
- means for connecting firstly the conductive carrier (7) or conductive zones (13) of the carrier, and secondly the conductive part (3) of the dispensing means to an electric generator, and
- means for positioning and/or moving the carrier and/or the dispenser means relative to one another and to place them in contact such as to carry out several ligand deposits on the carrier at different sites.
Device for producing a matrix of ligands on a conductive carrier or on conductive zones of a carrier, comprising:
- an electrode (15) in wire or needle form able to be charged externally with said ligand,
- means for connecting firstly the conductive carrier (7) or conductive zones (13) of the carrier, and secondly the electrode (15) to an electric generator, and
- means for positioning and/or moving the carrier and/or electrode (15) relative to one another such as to carry out several ligand deposits on the carrier at different sites.
Dependencies are inferred from the claim text.