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AssigneeHoffmann Technologies Corporation
InventorGeoffrey Hoffmann
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The invention describes methods for proteomic analysis involving the mapping of samples in N-dimensional shape space. The applications include the classification of samples on the basis of the three-dimensional shapes of substances they contain. A panel of P (>>1) reagents, with P≧N, called X(j), with j=1 to P, is used. The binding strength of each of the X(j) reagents to each other is a P×P matrix. This matrix is used to define another set of P reagents called Y(j), with j=1 to P, each of which is a linear combination of the X(j) reagents and each of which is complementary to one of the X(j) reagents. N of the X(j) reagents together with the corresponding Y(j) reagents are used to define a shape space that has N approximately orthogonal axes. The definition of these axes facilitates classification of samples. Methods for measuring similarity between pairs of samples and between sets of samples in the context of the set of N reagent pairs X(j) and Y(j) with j=1 to N are described. Applications include classification of samples, quality control, methods of diagnosis, and formulation of vaccines.
A method for mapping a sample i, in an N-dimensional shape space with approximately orthogonal axes, where N is an integer, comprising:
A method for predicting development of a disease in a vertebrate, comprising:
An ELISA plate for measurement of Proteomic Analyser points, said plate comprising 2N wells, wherein a first group of N wells are each coated with one of N reagents X(j) and a second group of N wells are each coated with one of N reagents Y(j), where N>>1, and the Y(j) reagents are mixtures of the X(j) reagents wherein relative concentrations of kth components X(k) in each reagent Y(j) is proportional to Kjk, where Kjk is a binding signal for binding of X(j) to X(k).
A set of reagents for use in classification of samples, medical diagnosis, therapeutic treatment of disease, vaccination, or immunization, said set of reagents comprising 2N reagents, wherein said set of reagents is made up of N X(j) reagents and N Y(j) reagents, wherein said Y(j) reagents are linear combinations of said X(j) reagents such that concentrations of kth components of Y(j) (j=1 to N;
Dependencies are inferred from the claim text.