Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists

A compound according to Formula (I):

• including all stereoisomers, solvates, prodrug esters and pharmaceutically acceptable salt forms thereof, wherein:
• X is selected from the group consisting of —S—, —S(═O)—, —S(═O)2— and —NR10—;
• R1 is selected from the group consisting of
• H, C(═O)R2a, C(═O)OR2a, S(═O)R2a, S(═O)2R2a,
• C3-7 cycloalkyl,
• C1-3 haloalkyl,
• C1-4 alkyl substituted with 0-3 R2,
• C2-4 alkenyl substituted with 0-2 R2,
• C2-4 alkynyl substituted with 0-2 R2,
• aryl substituted with 0-5 R42;
• C3-10 carbocyclic residue substituted with 0-3 R21, and
• 5-6 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R21;
• R2, at each occurrence, is independently selected from
• halo, C1-3 haloalkyl, C1-4 alkoxy, C1-4 alkyl,
• C2-4 alkenyl, C2-4 alkynyl, C3-6 cycloalkyl,
• aryl substituted with 0-5 R21;
• C3-10 carbocyclic residue substituted with 0-3 R21, and
• 5-6 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R21;
• R2a is selected from the group consisting of H, C1-4 alkyl, (aryl)C1-4 alkyl-, or (C3-6 cycloalkyl)C1-4 alkyl-;
• R4a is selected from the group consisting of H or C1-4 alkyl;
• R5 is selected from the group consisting of H, C1-4 alkyl, —C(═O)(C1-4 alkyl), —C(═O)O(C1-4 alkyl), or C1-4 haloalkyl;
• R6 is selected from the group consisting of —CF3,
• C1-6 alkyl substituted with 0-2 R20,
• C2-6 alkenyl substituted with 0-2 R20,
• C2-6 alkynyl substituted with 0-1 R20,
• C3-10 carbocyclic residue substituted with 0-3 R21,
• aryl substituted with 0-5 R21,
• 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R21;
• R7, R8, and R9 are H;
• R10 is H or C1-4 alkyl;
• R20 is selected from
• H, halo, —OH, —CF3, —CN, —NO2, —CO2H, —SO2R45,
• —SOR45, —SR45, —NR46SO2R45, —NR46COR45, —NR46R47,
• C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 alkoxy,
• C1-4 haloalkyl;
• C3-10 carbocyclic residue substituted with 0-3 R21;
• aryl substituted with 0-5 R21;
• and
• 5-10 membered heterocyclic ring system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R21;
• R21, at each occurrence, is independently selected from H, OH, halo, CF3, SO2R45, NR46R47, CN, NO2, C1-4 alkyl;
• C2-8 alkenyl, C2-8 alkynyl, C1-4 alkoxy, and C1-4 haloalkyl;
• R45 is C1-4 alkyl;
• R46, at each occurrence, is independently selected from H and C1-4 alkyl;
• R47, at each occurrence, is independently selected from H, C1-4 alkyl, —C(═O)NH(C1-4 alkyl), —SO2(C1-4 alkyl), —C(═O)O(C1-4 alkyl), —C(═O)(C1-4 alkyl), and —C(═O)H;
• and
• m is 1 or 2.