Intermolecular SNAr of the heterocycle-activated nitro and fluoro groups-application in the synthesis of polyazamacrocyclic ligands

A compound of formula I:

• wherein:
• R1 and R2 are the same or different and are selected from the group consisting of H, alkyl, cycloalkyl, alkenyl, alkynyl, hydroxyl, halide, nitro, carboxylate, amino, amido, epoxide, and labeling reagents;
• R3 is optional and is selected from the group consisting of an oxo, a terminal epoxide, alkyl, branched alkyl, cycloalkyl, hydroxyl, halide, nitro, carboxylate, amido, epoxide, amino, substituted amino, aryl, or vinyl group;
• R4-R7 are the same or different and are selected from the group consisting of H, alkyl, cycloalkyl, hydroxyl, halide, nitro, carboxylate, amido, epoxide, amino, substituted amino, aryl, vinyl, acetal, aldehyde, and labeling reagents;
• R8-R11 are the same or different and are selected from the group consisting of H, linear alkyl, branched alkyl, cycloalkyl, hydroxyl, halide, nitro, carboxylate, amido, epoxide, amino, substituted amino, aryl, acetal, aldehyde, and vinyl;
• X is a heteroatom selected from O, S, Se, NH, PH, AsCH2;
• and
• n is 0-5;
• or a derivative, or metabolite thereof.