Compositions and methods of enhanced transdermal delivery of steroid compounds and preparation methods
AssigneePharmaceutical Industry Technology and Development Center
InventorsChih-Chiang Yang, Yuan-Chih Le, Chao-Cheng Liu
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Abstract
Enhanced transdermal composition comprising a niosome, which retains within its structure a cyclodextrin inclusion complex of a steroidal active agent and a vesicle of nonionic surfactant are provided herein, which increases the permeability of dermal tissue to transdermally administered steroidal active agents. Methods for producing the enhanced transdermal composition as well as its application are also provided.
Claims19
A composition comprising a niosome, wherein the niosome retaining within its structure:
- (1) a cyclodextrin inclusion complex formed by a cyclodextrin compound and a steroidal active agent;
- and
- (2) a vesicle formed by a nonionic surfactant;
- wherein said niosome can facilitate the transdermal delivery of said steroidal active agent.
A method of producing a composition comprising a niosome, wherein the niosome retaining within its structure:
- (1) a cyclodextrin inclusion complex formed by a cyclodextrin compound and a steroidal active agent;
- and
- (2) a vesicle formed by a nonionic surfactant;
- wherein said niosome can facilitate the transdermal and/or transmucosal delivery of said steroidal active agent,
- the method comprising the steps of:
- (a) forming a cyclodextrin inclusion complex of a steroidal active agent;
- (b) forming a vesicle solution of a nonionic surfactant;
- (c) mixing the vesicle solution of step (b) with the cyclodextrin inclusion complex of step (a) in a molar ratio of about 1.0 to 25.0;
- and
- (d) drying the resulted mixture of step (c).
Dependencies are inferred from the claim text.