Pharmaceutical composition
OwnerLawrence Penkler, Barry Daisleyinventors
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Abstract
This invention relates to a pharmaceutical composition containing an inclusion complex of propofol and a water soluble cyclodextrin, in freeze dried form. The invention also relates to a process for producing the composition and the composition in unit dose form.
Claims13
A pharmaceutical composition in freeze dried form comprising an inclusion complex of propofol and a water soluble cyclodextrin, wherein the molar ratio of propofol to cyclodextrin is 1:greater than 1.
A pharmaceutical composition in freeze dried form comprising an inclusion complex of propofol and a water soluble cyclodextrin, and a lyoprotectant.
A pharmaceutical composition in unit dose form, the pharmaceutical composition being freeze dried and comprising an inclusion complex of propofol and a water soluble cyclodextrin, the unit dose containing from 50 mg to 400 mg inclusive of propofol.
A method of making a pharmaceutical composition in freeze dried form comprising an inclusion complex of propofol and a water soluble cyclodextrin, including the steps of:
- (a) preparing a solution of propofol and the cyclodextrin, containing greater than 70% mass to volume of the cyclodextrin;
- and
- (b) subjecting the solution of step (a) to a rapid freezing cycle and subsequently freeze drying to complete dryness to give the freeze dried pharmaceutical composition.
Dependencies are inferred from the claim text.