Topical anesthesia of the urinary bladder
OwnerRichard Henryinventor
Life of this patent
Estimating the term…
Abstract
An aqueous solution of local anesthetic is instilled into the urinary bladder in sufficient concentration with the addition of an alkalinizing agent such as sodium bicarbonate to elevate the intra-vesical pH to approximately 8.0. The combination is left in situ in the bladder for at least fifteen minutes to allow time for absorption of the base form of the local anesthetic. This method provides safe and effective topical anesthesia to allow pain-free cystoscopic biopsy and cautery of bladder lesions such as bladder cancer, and provides a means to treat inflammatory conditions of the bladder such as chronic interstitial cystitis and acute bacterial cystitis.
Claims16
A method for anesthetizing the bladder of a patient in need thereof, comprising the step of providing a sufficient quantity of a local anesthetic and an alkalinizing agent to the bladder of said patient to anesthetize the bladder, said local anesthetic and said alkalinizing agent being provided to said bladder separately, said local anesthetic being provided as an aqueous solution, said alkalinizing agent being provided in sufficient quantity to raise the pH of the bladder to approximately the pKA of the local anesthetic to convert at least a portion of said local anesthetic to its base form.
A pharmaceutical combination for anesthetizing a patient's bladder comprising:
- a sufficient quantity of a local anesthetic to anesthetize said patient's bladder;
- and
- a sufficient quantity of an alkalinizing agent to raise the pH of said patient's bladder to a level which causes the conversion of said local anesthetic to its base form, wherein said local anesthetic and said alkalinizing agent are positioned in a single-use, disposable syringe which maintains the local anesthetic and said alkalinizing agent separate until instilled in the bladder.
A method for treating interstitial cystitis, comprising the steps of periodically administering to a patient in need thereof a sufficient quantity of a local anesthetic and an alkalinizing agent, said local anesthetic and said alkalinizing agent being provided to said bladder separately, said local anesthetic and alkalinizing agent being provided to the bladder of said patient to anesthetize the bladder, said local anesthetic being provided in an aqueous solution, said alkalinizing agent being provided in sufficient quantity to raise the pH of the bladder to approximately the pKa of the local anesthetic to convert at least a portion of said local anesthetic to its base form.
Dependencies are inferred from the claim text.