Multiblock biodegradable hydrogels for drug delivery and tissue treatment

A pharmaceutical formulation of a gel-forming macromer, comprising

• a macromer comprising at least four covalently linked polymeric blocks, at least one thermally sensitive region, and at least one covalently crosslinkable group, and wherein at least two of the blocks are hydrophobic, and at least two of the blocks are hydrophilic,
• said macromer being dispersed or solubilized in a pharmaceutically acceptable aqueous solution or suspension,
• whereby the formulation is capable of reversibly transitioning from a liquid state to a gel state by an increase in temperature.