Biomedical adhesive
AssigneeCommonwealth Scientific and Industrial Research Organisation
InventorTimothy Hughes
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Abstract
The biomedical adhesives of the invention provide a reactive surface to adhere or crosslink to tissue and may be used, for example, as ready-to-use corneal onlay in ophthalmic surgery. The invention provides a method for bonding a bulk material to a corresponding nucleophilic or electrophilic surface including attaching a multifunctionally activated bulk material compound to the bulk material and contacting a functional group of the compound with the surface under conditions permitting covalent linkage between the bulk material and the functional group.
Claims35
A method for bonding an inorganic or organic bulk material to a nucleophilic or electrophilic surface including:
- attaching a multifunctionally activated compound to the bulk material, the compound selected to be electrophilic or nucleophilic opposite to the surface;
- then contacting the multifunctionally activated compound with the surface under conditions permitting covalent linkage between the surface and the multifunctionally activated compound.
A bioadhesive material attached to a bulk material for bonding the bulk material to a biological surface, the bioadhesive comprising a multifunctionally activated compound reactable with nucleophilic or electrophilic functional groups of the surface.
A biomedical device for attaching to a biological surface by a bioadhesive including a biocompatible organic or inorganic bulk material to which a multifunctionally activated compound has been bound, the bound multifunctionally actived compound being capable of being stored anhydrously.
A process for applying a bioadhesive to a surface of a biomedical device comprising a biocompatible organic or inorganic bulk material including the steps of
- if the surface is not nucleophilic or electrophilic, applying nucleophilic or electrophilic functional groups to the surface,
- covalently bonding to the surface a multifunctionally activated compound, the compound selected to be electrophilic or nucleophilic opposite to the fuctional groups,
- washing the surface of unbound multifunctionally activated compound.
A process for applying a bioadhesive to a surface of a biomedical device comprising a biocompatible organic or inorganic bulk material including the steps of
- if the surface is not nucleophilic or electrophilic, applying nucleophilic or electrophilic functional groups to the surface,
- covalently bonding the functional groups to a natural or synthetic polymer comprising co-reactive groups,
- covalently coupling to the natural or synthetic polymer a multifunctionally activated compound, the compound selected to be electrophilic or nucleophilic opposite to the co-reactive groups,
- washing the natural or synthetic polymer of unbound multifunctionally activated compound.
Dependencies are inferred from the claim text.