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US 2005/0233371 A1Published application
CNG2B: a novel human cyclic nucleotide-gated ion channel
AssigneeIcagen, Inc.
InventorsChristopher Creech, Timothy Jegla
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Abstract
The invention provides isolated nucleic acid and amino acid sequences of CNG2B, antibodies to CNG2B, methods of detecting CNG2B, and methods of screening for modulators of cyclic nucleotide-gated ion channels using biologically active CNG2B. The invention further provides, in a computer system, a method of screening for mutations of human CNG2B genes as well as a method for identifying a three-dimensional structure of human CNG2B polypeptides.
Claims8
1-10. (canceled)
An isolated polypeptide comprising a subunit of a cation channel, the polypeptide:
- (i) forming, with at least one cyclic nucleotide gated cation channel (CNG) alpha subunit, a cation channel having the characteristic of cyclic nucleotide-gating;
- and
- (ii) comprising an amino acid sequence of SEQ ID NO:1.
(canceled)
(canceled)
17-40. (canceled)
Dependencies are inferred from the claim text.