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OwnerCarl Merril, Sankar Adhya +1inventors
InventorsCarl Merril, Sankar Adhya, Dean Scholl
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This disclosure provides methods of selecting a therapeutic bacteriophage and identifying bacteria in a sample. The sample may be obtained from a plant or animal subject diagnosed with a disease caused by a bacterial infection or an object suspected of being exposed to a bacterium. The activity of reporter molecules, either encoded in the bacteriophage genome or added during sample analysis, is used to determine whether bacteriophages are capable of infecting assayed bacteria. Also provided are methods of selecting a bacteriophage for potential use in treating of bacterial infection, based upon the selectivity of the bacteriophage host range for the bacterium. The bacteriophages or bacteria may be immobilized in an array, such that multiple bacteriophages and/or bacteria may be assayed. Kits are also provided.
A method for selecting a bacteriophage capable of infecting a target bacterium, comprising:
A kit for selecting a bacteriophage capable of infecting a target bacterium, comprising:
A method of identifying a bacterium that falls within the host range of a bacteriophage, comprising:
A method of treating a bacterial infection in a host, comprising:
A device for selecting bacteriophages that are capable of infecting target bacteria, the device comprising:
Dependencies are inferred from the claim text.