Metal complex compounds
AssigneeGe Healthcare Limited
InventorsJo Klaveness, Pal Rongved
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Abstract
The invention relates to metal complex compounds, contrast agents for MRI and in vivo NMR markers for NMR spectroscopy comprising said metal complex compounds and methods for in vivo determination of physiological parameters, e.g. enzyme activity or pH using said metal complex compounds.
Claims18
A metal complex compound comprising a paramagnetic chelate comprising a paramagnetic metal ion M and a chelating agent, said chelating agent comprises at least one fluorine atom and a molecular moiety X, wherein the coordination distance between X and M changes upon influence of a physiological parameter and thereby changing the chemical shift of the at least one fluorine atom.
Dependencies are inferred from the claim text.