Novel statine derivatives for the treatment of Alzheimer's disease

A compound of the formula

• wherein
• R1 represents a hydrogen atom or a group selected from the formulae (A) and (B)
• (A) R3—CO—(CH2)s—CO—,
• in which
• R3 represents R4-Z1 with Z1 being O or NR5, R4, R5 being each independently hydrogen or C1-6 alkyl, and
• s is an integer from 1 to 4;
• (B) R6—CO—
• in which
• R6 represents a C1-6alkyl group, a C1-6 haloalkyl group or a phenyl group being optionally substituted by one or more substituents selected from the group consisting of halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, amino, C1-6 alkylamino, di-(C1-6 alkyl)-amino, C1-6 alkoxycarbonyl, formyl, carboxy, hydroxy, cyano, SO3H and nitro;
• Xaa1 each independently represent an amino acid or the N-alkylated derivative thereof, at least one of which being N-terminally linked to R1;
• n is 0 or an integer from 1 to 3;
• Y represents a single bond, or if t is 0, a spacer group selected from —O— and —NH—;
• R2 represents a hydroxy group or a group of formula (C)
• (C) -Z2-R7
• in which
• Z represents O or NR8,
• R7 represents
• (a) a C1-6 alkyl group being optionally substituted by one or more substituents selected from the group consisting of halogen, C3-8-cycloalkyl, phenyl, C1-6 alkoxy, C1-6 haloalkoxy, amino, C1-6 alkylamino, di-(C1-6 alkyl)-amino, C1-6 alkoxycarbonyl, formyl, carboxy, hydroxy, cyano and nitro, or
• (b) a phenyl group being optionally substituted by one or more substituents selected from the group consisting of halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, amino, C1-6 alkylamino, di-(C1-6 alkyl)-amino, C1-6 alkanoylamino, C1-6 alkoxycarbonyl, formyl, carboxy, hydroxy, cyano and nitro,
• R2 represents a hydrogen atom or C1-6 alkyl group;
• Xaa2 each independently represent an amino acid or the N-alkylated derivative thereof, in which the amino group of the N-terminally amino acid may have been replaced by Y, and one of which being C-terminally linked to R2;
• t is 0 or an integer from 1 to 3;
• X is selected from ethyl, thiomethyl and C3-C8-cycloalkyl;
• and
• m is 1 or 2,
• or a pharmaceutically acceptable salt or solvate thereof.