Peptides that promote complement activation
AssigneesBaxter International Inc., Baxter Healthcare S.A.
InventorsRichard Johnson, Shelley Maves
Life of this patent
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Abstract
The present invention relates to compositions, including pharmaceutical compositions that promote complement activation, and contain a polypeptide X1-C-X2-X3-X4-X5-X6-X7-X8-C-X9 as described. The invention further relates to a method of promoting complement activation in a patient by administering a pharmaceutical composition as described herein. Further provided are a wound dressing and an anti-tumor cell antigen antibody formulation containing pharmaceutical compositions of the present invention.
Claims45
A composition for promoting complement activation, said composition comprising a polypeptide comprising the sequence X1-C-X2-X3-X4-X5-X6-X7-X8-C-X9, wherein
- C is cysteine;
- X1 is a hydrogen atom, an amino acid residue, or a bond covalently linking the polypeptide to another component of the composition;
- X2 is a neutral non-polar amino acid residue;
- X3 is a neutral polar amino acid residue;
- X4, X5, X6, and X7 are independently any amino acid residue;
- X8 is a neutral non-polar amino acid residue;
- and
- X9 is a hydrogen atom, an amino acid residue, or a bond covalently linking the polypeptide to another component of the composition.
A composition for promoting complement activation, said composition comprising a polypeptide comprising the sequence X1-C-X2-X3-X4-X5-X6-X7-X8-C-X9 wherein:
- C is cysteine;
- X1, X4, X5, X6, X7, and X9 are independently an amino acid residue;
- X2 is leucine or proline;
- X3 is serine or glycine;
- and
- X8 is methionine or trypthophan.
A pharmaceutical composition for promoting complement activation, said composition comprising a polypeptide comprising the sequence X1-C-X2-X3-X4-X5-X6-X7-X8-C-X9 and a pharmaceutically effective carrier or excipient, wherein
- C is cysteine;
- X1 is a hydrogen atom, an amino acid residue, or a bond covalently linking the polypeptide to another component of the composition;
- X2 is a neutral non-polar amino acid residue;
- X3 is a neutral polar amino acid residue;
- X4, X5, X6, and X7 are independently any amino acid residue;
- X8 is a neutral non-polar amino acid residue;
- and
- X9 is a hydrogen atom, an amino acid residue, or a bond covalently linking the polypeptide to another component of the composition.
Dependencies are inferred from the claim text.