Inhibition of neurodegeneration
AssigneeRhode Island Hospital
InventorsJack Wands, Suzanne de la Monte
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Abstract
The invention features a non-transgenic model of Alzheimer's Disease, method for inducing prolonged in vivo gene expression in a mammal, and methods of inhibiting Alzheimer's Disease-associated neuronal cell death.
Claims45
A method for inducing prolonged in vivo gene expression in a mammal, comprising contacting a non-muscular tissue with a composition comprising a nucleic acid, a histone, and an amphipathic compound.
21-26. (canceled)
A non-transgenic model for Alzheimer' Disease, comprising a non-human animal, wherein said animal comprises a exogenous nitric oxide synthase nucleic acid.
A method of inhibiting Alzheimer's Disease-associated neuronal cell death, comprising contacting an AD7c-NTP-overexpressing cell with a composition comprising an AD7c-NTP antisense nucleic acid and a histone polypeptide,
A method of inhibiting Alzheimer's Disease-associated neuronal cell death, comprising contacting an AD7c-NTP-overexpressing cell with an inhibitor of insulin or insulin-like growth factor-1 dependent signal transduction.
A method of inhibiting Alzheimer's Disease-associated neuronal cell death, comprising contacting an AD7c-NTP-overexpressing cell with an inhibitor of an IRS-dependent growth factor.
A method of inhibiting Alzheimer's Disease-associated neuronal cell death, comprising contacting an Adc7-NTP-overexpressing cell with an inhibitor of nitric oxide synthase III.
A method of inhibiting Alzheimer's Disease-associated neuronal cell death, comprising contacting an Adc7-NTP-overexpressing cell with an inhibitor of insulin.
A method of identifying a compound which inhibits Alzheimer's Disease-associated neuronal cell death, comprising contacting an AD7c-NTP over-expressing cell with a candidate compound and measuring cell viability, wherein an increase in cell viability in the presence of the compound compared to in its absence indicates that said compound inhibits Alzheimer's Disease associated neuronal cell death.
-52 (cancel).
Dependencies are inferred from the claim text.