Pseudomonas virulence factors and uses thereof
OwnerStephen Calderwood, Ji Choi +4inventors
InventorsStephen Calderwood, Ji Choi, Costi Sifri, Boyan Goummerv, Laurence Rahme, Frederic Ausubel
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Abstract
Disclosed are bacterial virulence polypeptides and nucleic acid sequences (e.g., DNA) encoding such polypeptides, and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial or bacteriostatic compounds.
Claims19
An isolated polypeptide comprising an amino acid sequence having at least 30% identity to the amino acid sequence of YbtQ (SEQ ID NO:2), wherein expression of said polypeptide in a microorganism affects the virulence of said microorganism.
An isolated nucleic acid molecule having at least 30% identity to the nucleotide sequence of ybtQ (SEQ ID NO:1) encoding the YbtQ polypeptide (SEQ ID NO:2), wherein expression of said nucleic acid molecule, in a microorganism, affects the virulence of said microorganism.
Dependencies are inferred from the claim text.