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AssigneesTissue Regeneration, Inc., Trustees of Tufts College
InventorsGregory Altman, David Kaplan, Rebecca Horan, David Horan
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The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.
A fiber construct comprising sericin-extracted silkworm fibroin fibers, wherein the fibers have a diameter of about 20 to about 40 μm and an average ultimate tensile strength of at least about 0.67 N/fiber.
A method for producing a sericin-extracted silk-fibroin fiber construct comprising:
A method for producing a sericin-extracted silk-fibroin fiber construct comprising:
A method for producing a sericin-extracted silk-fibroin fiber construct comprising:
A method for producing a sericin-extracted silk-fibroin fiber construct comprising:
A method for producing a sericin-extracted silk-fibroin fiber construct comprising:
Dependencies are inferred from the claim text.