Pharmaceutical formulation containing dye
AssigneeThomas J. Gruber
InventorThomas Gruber
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Abstract
Methods and compositions for preventing abuse of dosage forms comprising an opioid analgesic and an aversive agent (e.g., a dye) in an effective amount to deter an abuser from administering a tampered form of the dosage form intravenously, intranasally, and/or orally are revealed.
Claims26
An oral dosage form comprising:
- a therapeutically effective amount of an oploid analgesic;
- and a dye at least partially interdispersed with the opioid;
- wherein the oral dosage form releases the dye upon tampering of the dosage form.
A method of preparing a pharmaceutical oral dosage form comprising combining a therapeutically effective amount of an opioid analgesic in an oral dosage form with an effective amount of a dye wherein the dye is at least partially interdispersed with the opioid analgesic and the oral dosage form releases the dye upon tampering of the dosage form.
Dependencies are inferred from the claim text.