Substituted heterocyclic compounds and methods of use

A compound of formula

• or a pharmaceutically acceptable salt thereof, wherein
• n is 0, 1 or 2;
• R1 is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, wherein the ring may be fused with a benzo group, and is substituted by 0, 1 or 2 oxo groups, and wherein R1 is additionally substituted by 0, 1, 2 or 3 substituents selected from Rd and C1-4alkylRd;
• R2 is C1-6alkyl substituted by 1, 2 or 3 Rd groups and 0 or 1 Rc groups, which are substituted by 0, 1 or 2 Rd groups, wherein R2 is not —C(═O)Obenzyl;
• and wherein —R1-R2 is not 3-benzylpiperazin-1-yl;
• and wherein if R3 and R4 are both 4-methylphenyl then —R1-R2 is not 4-(hydroxymethyl)piperidin-1-yl;
• R3 is Rc substituted by 0, 1, 2 or 3 substituents selected from Rf and Rd;
• R4 is Rc substituted by 0, 1, 2 or 3 substituents selected from Rf and Rd not including 1-phenylethylamino;
• provided that the total number of Rc groups substituted on each of R3 and R4 is 0 or 1;
• R5 is independently at each instance H, C1-8alkyl or C1-6alkylRc both of which are substituted by 0, 1, 2 or 3 substituents selected from Rd;
• R6 is independently at each instance C1-8alkyl or C1-6alkylRc both of which are substituted by 0, 1, 2 or 3 substituents selected from Rd;
• or R6 is Rd;
• R7 is independently hydrogen, —C1-6alkyl or —C1-4alkylRc wherein any carbon atom in the preceding is substituted by 0-3 substituents selected from Rd;
• Ra is independently at each instance H or Rb;
• Rb is independently at each instance C1-8alkyl, Rc or C1-4alkylRc each of which is substituted by 0, 1, 2 or 3 substituents independently selected from Rd;
• Rc is independently at each instance aryl or a saturated or unsaturated 5-, 6- or 7-membered heterocyclic ring containing 1, 2 or 3 atoms selected from N, O and S, wherein the ring is fused with 0 or 1 benzo groups and 0 or 1 saturated or unsaturated 5-, 6- or 7-membered heterocyclic ring containing 1, 2 or 3 atoms selected from N, O and S;
• wherein any heterocyclic ring is substituted by 0, 1 or 2 oxo groups;
• Rd is independently in each instance C1-6alkyl, halo, C1-4haloalkyl, cyano, —C(═O)Rf, —C(═O)ORe, —C(═O)NRgRg, —C(═NRg)NRgRg, —ORe, —OC(═O)Re, —OC(═O)NRgRg, —OC(═O)N(Rh)S(═O)2Rf, —SRe, —S(═O)Rf, —S(═O)2Rf, —S(═O)2NRgRg, —S (═O)2N(Rh)C(═O)Rf, —S(═O)2N(Rh)C(═O)ORf, —S(═O)2—N(Rh)C(═O)NRgRg, —NRgRg, —N(Rh)C(═O)Re, —N(Rh)C(═O)ORf, —N(Rh)C(═O)NRgRg, —N(Rh)C(═NRg)NRgRg, —N(Rh)S(═O)2Rf or —N(Rh)S(═O)2NRgRg;
• Re is independently at each instance hydrogen or Rf
• Rf is independently at each instance Rc or C1-8alkyl, either of which is substituted by 0-3 substituents selected from —NRgRh, —C(═O)ORi, —ORi, —N(Ri)C(═O)Rk, —N(Ri)C(═O)ORi, —N(Ri)S(═O)2Rk, —S(═O)nRk, cyano, halo, —OC1-4alkylRc, —S(═O)nC1-4alkylRc and Rc, wherein any Rc in Rf may be further substituted by C1-8alkyl or C1-4haloalkyl;
• Rg is independently at each instance hydrogen, Rc, C1-10alkyl or —C1-4alkylRc, wherein the each is substituted by 0-3 substituents selected from —NRiRi, —N(Ri)C(═O)Rk, —N(Ri)C(═O)ORk, N(Ri)S(═O)2Rk, —ORi, —S(═O)nRk, cyano, C1-8alkyl and C1-4haloalkyl;
• Rh is independently at each instance hydrogen, C1-8alkyl or C1-4alkylRc each of which is substituted by 0-3 substituents selected from —NRiRi, RN(Ri)C(═O)Rk, —N(Ri)C(═O)ORk, —N(Ri)S(═O)2Rk, —ORi, —S(═O)nRk, cyano, C1-8alkyl and C1-4haloalkyl;
• Ri is Rk or hydrogen;
• Rk is C1-6alkyl, phenyl or benzyl;
• V is —N═, —NR5—, —CR6═, C═O, C═S or C═NR;
• W is —N═, —NR5—, —CR6═, C═O, C═S or C═NR7;
• and
• X is —N═, —NR5—, —CR6═, C═O, C═S or C═NR7;
• wherein the total number of —NR5—, C═O, C═S or C═NR7 groups represented by V, W and X must be 0 or 2;
• and at least one of V, W and X contains a N atom.