Effect of bone morphogenetic proteins on engineered cartilage
OwnerLisa Freed, Keith Gooch +4inventors
InventorsLisa Freed, Keith Gooch, Donald Courter, Torsten Blunk, Alisha Sieminski, Gordana Vunjak-Novakovic
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Abstract
Compositions and methods comprising at least one active agent chosen from TGF-P superfamily proteins, including BMPs, and GDFs for increasing the growth rate or modulating the development of engineered cartilage are disclosed. The compositions are useful in the treatment of osteoarthritis, cartilage defects, and in related tissue repair.
Claims19
A composition for increasing the growth rate or modulating the development of engineered cartilage comprising
- a) at least one active agent chosen from TGF-β superfamily proteins;
- and
- b) at least one of biomaterial scaffold, suture, allograft, or autograft as a carrier.
A method for increasing the growth rate or modulating the development of cartilage comprising:
- adding a composition comprising
- a) at least one active agent chosen from TGF-β superfamily proteins;
- and
- b) at least one of biomaterial scaffold, suture, allograft, or autograft as a carrier
- in an amount effective for increasing the growth rate or modulating the development of the cartilage.
Dependencies are inferred from the claim text.