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OwnerBenny Lo, Laughton Charles Anthony +1inventors
InventorsBenny Lo, Laughton Charles Anthony, Michael Price
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A humanised antibody capable of binding to the MUC1 mucin antigen comprises a light chain and a heavy chain. The variable region of the light chain (VL) comprising an amino acid sequence which is substantially homologous with the sequence of FIG. 1A and the variable region of the heavy chain (VH) comprising an amino acid sequence which is substantially homologous with the sequence of FIG. 1B. The amino acid residue at position 46 on VL is backmutated to arginine, and the amino acid residue at position 47 on VH is backmutated to leucine. The humanised antibody has use in the diagnosis and/or treatment of cancer.
A humanized antibody capable of binding to a MUC1 mucin antigen comprising a light chain and a heavy chain, the variable region of the light chain (VL) comprising an amino acid sequence which is substantially homologous with the sequence of FIG. 1A, the variable region of the heavy chain (VH) comprising an amino acid sequence which is substantially homologous with the sequence of FIG. 1B, wherein the amino acid residue at position 46 on VL is backmutated to arginine, and wherein the amino acid residue at position 47 on VH is backmutated to leucine.
A humanised humanized antibody as claimed in any preceding claim in which the amino acid residue at position 42 on VH is backmutated to aspartic acid.
Dependencies are inferred from the claim text.