Oligoribonucleotides alert the immune system of animals to the imminence of microbial infection
OwnerWilliam Marshallinventor
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Abstract
This invention provides novel methods and compositions for modulating and stimulating the immune system of animals to withstand microbial infections and the lethality of endotoxic shock by feeding or injecting bacteria-free oligoribonucleotides (ORNs) released by either harmless or pathogenic bacteria. The invention also describes the molecular mode of action of the health benefits derived from consuming fermented dairy products and probiotic bacteria.
Claims32
A composition for modulating and/or stimulating the immune system of an animal comprising an oligoribonucleotide (ORN) from bacteria having a molecular weight less than 10 kDa.
A method for modulating and/or stimulating the immune system of an animal comprising:
- growing bacteria in a medium;
- exposing said bacteria to biological, chemical or physical stress for at least one period of stress of approximately 10 to 20 minutes separating said medium and oligoribonucleotides (ORNs) from said bacteria to form a separated product;
- filtering said separated product to remove substances having a molecular weight of greater than 10 kDa to form a filtrate;
- administering said filtrate to said animal, so that the immune system is modulated and/or stimulated to withstand microbial infections.
A method for modulating and/or stimulating the immune system of an animal comprising:
- (a) preparing an immunopotentiating composition having the ability to stimulate an immune response which composition comprises a mixture of oligoribonucleotides (ORNs) with a molecular weight less than 10 kDa;
- (b) combining the composition in a pharmaceutically acceptable carrier;
- and
- (c) administering the resulting composition to said animal in an amount effective to stimulate an immune response so that the immune system of the animal is activated for suppressing microbial infections and the onset of endotoxic shock.
Dependencies are inferred from the claim text.