Back to results
US 2005/0032697 A1Published application
Heparin binding VEGFR-3 ligands
OwnerKari Alitalo, Yulong He +1inventors
InventorsKari Alitalo, Yulong He, Toumas Tammela
Life of this patent
Estimating the term…
Abstract
The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-3 ligand and a heparin binding domain. The chimeric molecules of the present invention retain VEGFR-3 binding activity and an enhanced heparin binding activity as compared to native VEGF-C and/or VEGF-D.
Claims38
A compound comprising the formula X-B-Z or Z-B-X,
- wherein X binds Vascular Endothelial Growth Factor Receptor 3 (VEGFR-3) and comprises an amino acid sequence at least 90% identical to a VEGFR-3 ligand selected from the group consisting of:
- (a) the prepro-VEGF-C amino acid sequence set forth in SEQ ID NO:
- 2;
- (b) fragments of (a) that bind VEGFR-3;
- (c) the prepro-VEGF-D amino acid sequence set forth in SEQ ID NO:
- 4;
- and
- (d) fragments of (c) that bind VEGFR-3;
- wherein Z comprises a heparin-binding amino acid sequence;
- and
- wherein B comprises a covalent attachment linking X to Z.
8 more elements
Dependencies are inferred from the claim text.