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US 2005/0032683 A1Published application
Methods of modulating apoptosis by administration of relaxin agonists or antagonists
OwnerEdward Amento, Chrishan Samuelinventors
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Abstract
The present invention relates to the discovery that relaxin is associated with the development or maturation of body tissues. Knockouts of the gene encoding relaxin result in various abnormalities in the development of various tissues. The present invention provides methods of modulating apoptosis by administering a relaxin agonist or antagonist to a subject.
Claims52
A method of modulating apoptosis, comprising:
- administering to a subject in need thereof an effective amount of a relaxin agonist for a period of time sufficient to decrease apoptosis in cells expressing a relaxin receptor.
A method of modulating apoptosis in a population of cells expressing a relaxin receptor, comprising:
- administering to a subject in need thereof an effective amount of an antagonist of relaxin for a period of time sufficient to increase apoptosis in the cell population expressing the relaxin receptor.
Dependencies are inferred from the claim text.